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7TZC

A drug and ATP binding site in type 1 ryanodine receptor

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0003151biological_processoutflow tract morphogenesis
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0008144molecular_functionobsolete drug binding
A0014802cellular_componentterminal cisterna
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0015278molecular_functionintracellularly gated calcium channel activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030018cellular_componentZ disc
A0031090cellular_componentorganelle membrane
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034704cellular_componentcalcium channel complex
A0035381molecular_functionATP-gated ion channel activity
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043931biological_processossification involved in bone maturation
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048741biological_processskeletal muscle fiber development
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071313biological_processcellular response to caffeine
A0097718molecular_functiondisordered domain specific binding
A1990425cellular_componentryanodine receptor complex
B0003151biological_processoutflow tract morphogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006936biological_processmuscle contraction
B0006941biological_processstriated muscle contraction
B0008144molecular_functionobsolete drug binding
B0014802cellular_componentterminal cisterna
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0015278molecular_functionintracellularly gated calcium channel activity
B0015643molecular_functiontoxic substance binding
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030018cellular_componentZ disc
B0031090cellular_componentorganelle membrane
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034704cellular_componentcalcium channel complex
B0035381molecular_functionATP-gated ion channel activity
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043931biological_processossification involved in bone maturation
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048741biological_processskeletal muscle fiber development
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071277biological_processcellular response to calcium ion
B0071313biological_processcellular response to caffeine
B0097718molecular_functiondisordered domain specific binding
B1990425cellular_componentryanodine receptor complex
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processpositive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C0140056biological_processorganelle localization by membrane tethering
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0002027biological_processregulation of heart rate
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031954biological_processpositive regulation of protein autophosphorylation
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032516biological_processpositive regulation of phosphoprotein phosphatase activity
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035307biological_processpositive regulation of protein dephosphorylation
D0035458biological_processcellular response to interferon-beta
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0072542molecular_functionprotein phosphatase activator activity
D0097225cellular_componentsperm midpiece
D0098901biological_processregulation of cardiac muscle cell action potential
D0140056biological_processorganelle localization by membrane tethering
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
E0000086biological_processG2/M transition of mitotic cell cycle
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0007186biological_processG protein-coupled receptor signaling pathway
E0008076cellular_componentvoltage-gated potassium channel complex
E0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
E0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031954biological_processpositive regulation of protein autophosphorylation
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032516biological_processpositive regulation of phosphoprotein phosphatase activity
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035307biological_processpositive regulation of protein dephosphorylation
E0035458biological_processcellular response to interferon-beta
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050848biological_processregulation of calcium-mediated signaling
E0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0098901biological_processregulation of cardiac muscle cell action potential
E0140056biological_processorganelle localization by membrane tethering
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0008144molecular_functionobsolete drug binding
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0014802cellular_componentterminal cisterna
F0016020cellular_componentmembrane
F0016529cellular_componentsarcoplasmic reticulum
F0033017cellular_componentsarcoplasmic reticulum membrane
F0043231cellular_componentintracellular membrane-bounded organelle
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0098562cellular_componentcytoplasmic side of membrane
F1990425cellular_componentryanodine receptor complex
G0003151biological_processoutflow tract morphogenesis
G0005216molecular_functionmonoatomic ion channel activity
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005262molecular_functioncalcium channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005790cellular_componentsmooth endoplasmic reticulum
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0006874biological_processintracellular calcium ion homeostasis
G0006936biological_processmuscle contraction
G0006941biological_processstriated muscle contraction
G0008144molecular_functionobsolete drug binding
G0014802cellular_componentterminal cisterna
G0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0015278molecular_functionintracellularly gated calcium channel activity
G0015643molecular_functiontoxic substance binding
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0019722biological_processcalcium-mediated signaling
G0030018cellular_componentZ disc
G0031090cellular_componentorganelle membrane
G0033017cellular_componentsarcoplasmic reticulum membrane
G0034704cellular_componentcalcium channel complex
G0035381molecular_functionATP-gated ion channel activity
G0042383cellular_componentsarcolemma
G0042802molecular_functionidentical protein binding
G0043588biological_processskin development
G0043931biological_processossification involved in bone maturation
G0044325molecular_functiontransmembrane transporter binding
G0046872molecular_functionmetal ion binding
G0048741biological_processskeletal muscle fiber development
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051289biological_processprotein homotetramerization
G0055085biological_processtransmembrane transport
G0070588biological_processcalcium ion transmembrane transport
G0071277biological_processcellular response to calcium ion
G0071313biological_processcellular response to caffeine
G0097718molecular_functiondisordered domain specific binding
G1990425cellular_componentryanodine receptor complex
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0008144molecular_functionobsolete drug binding
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0014802cellular_componentterminal cisterna
H0016020cellular_componentmembrane
H0016529cellular_componentsarcoplasmic reticulum
H0033017cellular_componentsarcoplasmic reticulum membrane
H0043231cellular_componentintracellular membrane-bounded organelle
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0098562cellular_componentcytoplasmic side of membrane
H1990425cellular_componentryanodine receptor complex
I0003151biological_processoutflow tract morphogenesis
I0005216molecular_functionmonoatomic ion channel activity
I0005219molecular_functionryanodine-sensitive calcium-release channel activity
I0005245molecular_functionvoltage-gated calcium channel activity
I0005262molecular_functioncalcium channel activity
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005516molecular_functioncalmodulin binding
I0005524molecular_functionATP binding
I0005790cellular_componentsmooth endoplasmic reticulum
I0006811biological_processmonoatomic ion transport
I0006816biological_processcalcium ion transport
I0006874biological_processintracellular calcium ion homeostasis
I0006936biological_processmuscle contraction
I0006941biological_processstriated muscle contraction
I0008144molecular_functionobsolete drug binding
I0014802cellular_componentterminal cisterna
I0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0015278molecular_functionintracellularly gated calcium channel activity
I0015643molecular_functiontoxic substance binding
I0016020cellular_componentmembrane
I0016529cellular_componentsarcoplasmic reticulum
I0019722biological_processcalcium-mediated signaling
I0030018cellular_componentZ disc
I0031090cellular_componentorganelle membrane
I0033017cellular_componentsarcoplasmic reticulum membrane
I0034704cellular_componentcalcium channel complex
I0035381molecular_functionATP-gated ion channel activity
I0042383cellular_componentsarcolemma
I0042802molecular_functionidentical protein binding
I0043588biological_processskin development
I0043931biological_processossification involved in bone maturation
I0044325molecular_functiontransmembrane transporter binding
I0046872molecular_functionmetal ion binding
I0048741biological_processskeletal muscle fiber development
I0051209biological_processrelease of sequestered calcium ion into cytosol
I0051289biological_processprotein homotetramerization
I0055085biological_processtransmembrane transport
I0070588biological_processcalcium ion transmembrane transport
I0071277biological_processcellular response to calcium ion
I0071313biological_processcellular response to caffeine
I0097718molecular_functiondisordered domain specific binding
I1990425cellular_componentryanodine receptor complex
J0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0008144molecular_functionobsolete drug binding
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0014802cellular_componentterminal cisterna
J0016020cellular_componentmembrane
J0016529cellular_componentsarcoplasmic reticulum
J0033017cellular_componentsarcoplasmic reticulum membrane
J0043231cellular_componentintracellular membrane-bounded organelle
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0098562cellular_componentcytoplasmic side of membrane
J1990425cellular_componentryanodine receptor complex
K0000086biological_processG2/M transition of mitotic cell cycle
K0000922cellular_componentspindle pole
K0002027biological_processregulation of heart rate
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005876cellular_componentspindle microtubule
K0005886cellular_componentplasma membrane
K0007186biological_processG protein-coupled receptor signaling pathway
K0008076cellular_componentvoltage-gated potassium channel complex
K0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
K0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0021762biological_processsubstantia nigra development
K0030017cellular_componentsarcomere
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031954biological_processpositive regulation of protein autophosphorylation
K0031982cellular_componentvesicle
K0032465biological_processregulation of cytokinesis
K0032516biological_processpositive regulation of phosphoprotein phosphatase activity
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035307biological_processpositive regulation of protein dephosphorylation
K0035458biological_processcellular response to interferon-beta
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050848biological_processregulation of calcium-mediated signaling
K0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
K0051592biological_processresponse to calcium ion
K0055117biological_processregulation of cardiac muscle contraction
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0071902biological_processpositive regulation of protein serine/threonine kinase activity
K0072542molecular_functionprotein phosphatase activator activity
K0097225cellular_componentsperm midpiece
K0098901biological_processregulation of cardiac muscle cell action potential
K0140056biological_processorganelle localization by membrane tethering
K1901842biological_processnegative regulation of high voltage-gated calcium channel activity
K1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
K1902494cellular_componentcatalytic complex
K1905913biological_processnegative regulation of calcium ion export across plasma membrane
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
O0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0008144molecular_functionobsolete drug binding
O0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
O0014802cellular_componentterminal cisterna
O0016020cellular_componentmembrane
O0016529cellular_componentsarcoplasmic reticulum
O0033017cellular_componentsarcoplasmic reticulum membrane
O0043231cellular_componentintracellular membrane-bounded organelle
O0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
O0098562cellular_componentcytoplasmic side of membrane
O1990425cellular_componentryanodine receptor complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
KASP20-LEU32
KASP56-PHE68
KASP93-LEU105
KASP129-PHE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19136
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AMET1-ASN4558
GASN4662-LYS4779
GLYS4821-LYS4835
GGLY4941-SER5037
IMET1-ASN4558
IASN4662-LYS4779
ILYS4821-LYS4835
IGLY4941-SER5037
DASP58
DASN60
DTHR62
AASN4662-LYS4779
DGLU67
EASP20
EASP22
EASP24
ETHR26
EGLU31
EASP56
EASP58
EASN60
ETHR62
ALYS4821-LYS4835
EGLU67
CASP20
CASP22
CASP24
CTHR26
CGLU31
CASP56
CASP58
CASN60
CTHR62
AGLY4941-SER5037
CGLU67
BMET1-ASN4558
BASN4662-LYS4779
BLYS4821-LYS4835
BGLY4941-SER5037
GMET1-ASN4558

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4559-PHE4579
KGLU140
DASP93
DASP95
DASN97
DTYR99
DGLU104
DASP129
DASP131
DASP133
DGLN135
BPHE4559-PHE4579
DGLU140
EASP93
EASP95
EASN97
ETYR99
EGLU104
EASP129
EASP131
EASP133
EGLN135
GPHE4559-PHE4579
EGLU140
CASP93
CASP95
CASN97
CTYR99
CGLU104
CASP129
CASP131
CASP133
CGLN135
IPHE4559-PHE4579
CGLU140
KGLU104
KASP129
KASP131
KASP133
KGLN135

site_idSWS_FT_FI3
Number of Residues408
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
ATYR4580-GLU4640
GHIS4803
GASN4857-MET4879
GGLU4900-THR4919
ITYR4580-GLU4640
IHIS4803
IASN4857-MET4879
IGLU4900-THR4919
AHIS4803
AASN4857-MET4879
AGLU4900-THR4919
BTYR4580-GLU4640
BHIS4803
BASN4857-MET4879
BGLU4900-THR4919
GTYR4580-GLU4640

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APRO4641-TYR4661
BPRO4641-TYR4661
GPRO4641-TYR4661
IPRO4641-TYR4661

site_idSWS_FT_FI5
Number of Residues88
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4780-GLY4802
BPHE4780-GLY4802
GPHE4780-GLY4802
IPHE4780-GLY4802

site_idSWS_FT_FI6
Number of Residues64
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
ATYR4804-VAL4820
BTYR4804-VAL4820
GTYR4804-VAL4820
ITYR4804-VAL4820

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AGLN4836-PHE4856
BGLN4836-PHE4856
GGLN4836-PHE4856
IGLN4836-PHE4856

site_idSWS_FT_FI8
Number of Residues76
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AMET4880-ASP4899
BMET4880-ASP4899
GMET4880-ASP4899
IMET4880-ASP4899

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4920-PHE4940
BPHE4920-PHE4940
GPHE4920-PHE4940
IPHE4920-PHE4940

site_idSWS_FT_FI10
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN
ChainResidueDetails
AGLU3893
IGLU3893
IGLU3967
ITHR5001
AGLU3967
ATHR5001
BGLU3893
BGLU3967
BTHR5001
GGLU3893
GGLU3967
GTHR5001

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5T9V, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN, ECO:0007744|PDB:5TAS, ECO:0007744|PDB:5TAT, ECO:0007744|PDB:5TAU
ChainResidueDetails
ALYS4211
ILYS4211
IMET4954
ITHR4979
AMET4954
ATHR4979
BLYS4211
BMET4954
BTHR4979
GLYS4211
GMET4954
GTHR4979

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TAN
ChainResidueDetails
ATRP4716
BTRP4716
GTRP4716
ITRP4716

site_idSWS_FT_FI13
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
ASER1338
ISER1338
ISER2345
ISER4470
ASER2345
ASER4470
BSER1338
BSER2345
BSER4470
GSER1338
GSER2345
GSER4470

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269|PubMed:8380342
ChainResidueDetails
ASER2843
BSER2843
GSER2843
ISER2843

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948
ChainResidueDetails
ACYS3635
BCYS3635
GCYS3635
ICYS3635

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
ATHR4466
BTHR4466
GTHR4466
ITHR4466

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ATYR4863
BTYR4863
GTYR4863
ITYR4863

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ASER4866
BSER4866
GSER4866
ISER4866

222036

PDB entries from 2024-07-03

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