7TYV
Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glycoprotein G1 | polymer | 259 | 29098.4 | 3 | UniProt (P08669) Pfam (PF00798) | Lassa virus | |
| 2 | D, F, H (D, G, H) | 25.10C Fab Heavy Chain | polymer | 226 | 24270.3 | 3 | Homo sapiens | ||
| 3 | E, G, I (E, L, K) | 25.10C Fab Light Chain | polymer | 233 | 25501.5 | 3 | Homo sapiens | ||
| 4 | J, K, L (a, b, c) | Glycoprotein G2 | polymer | 164 | 19116.7 | 3 | UniProt (P08669) Pfam (PF00798) | Lassa virus | |
| 5 | M, Q, U (F, N, R) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 6 | N, O, R, S, V (I, V, O, P, S) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 7 | P (M) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
| 8 | T, X (Q, U) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G01760ZU) | |||
| 9 | W (T) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 10 | AA, BA, CA, DA, EA... (A, B, C, a, b...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 259 (UniProt: P08669)
a, b, c: 260 - 423 (UniProt: P08669)
| PDB | External Database | Details |
|---|---|---|
| Cys 207 | Arg 207 | engineered mutation |
| Arg 258 | Leu 258 | engineered mutation |
| Arg 259 | Leu 259 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 329 | Glu 329 | engineered mutation |
| Thr 332 | Met 332 | engineered mutation |
| Cys 360 | Gly 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 293960.6 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 8497.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2875.7 | |
| All* | Total formula weight | 305334.1 |
