7TW9
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to Sinefungin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transcription factor ETV6,Proofreading exoribonuclease nsp14 chimera | polymer | 309 | 35439.3 | 1 | UniProt (P41212) UniProt (P0DTD1) Pfam (PF02198) Pfam (PF06471) | Severe acute respiratory syndrome coronavirus 2 | ETS translocation variant 6,ETS-related protein Tel1,Tel,ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 2 | B (A) | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | E (A) | ETHANOL | non-polymer | 46.1 | 1 | Chemie (EOH) | |||
| 6 | F, G, H, I, J (A) | METHANOL | non-polymer | 32.0 | 5 | Chemie (MOH) | |||
| 7 | K (A) | water | water | 18.0 | 376 | Chemie (HOH) |
Sequence modifications
A: 2 - 78 (UniProt: P41212)
A: 300 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 4 | Arg 49 | engineered mutation |
| Glu 67 | Val 112 | engineered mutation |
| Ala 77 | Lys 122 | engineered mutation |
| Pro 79 | - | linker |
| Ala 80 | - | linker |
| Ala 81 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35439.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 759.2 | |
| All* | Total formula weight | 36198.5 |
