7TVE

ATP and DNA bound SMC5/6 core complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA (68-MER)	polymer	68	21253.1	1		synthetic construct
2	B (B)	DNA (78-MER)	polymer	78	23682.1	1		synthetic construct
3	C (C)	Non-structural maintenance of chromosomes element 1	polymer	337	38437.4	1	UniProt (A0A7I9FFW3) Pfam (PF07574) Pfam (PF08746) UniProt (by SIFTS) (Q07913)	Saccharomyces cerevisiae W303
4	D (D)	Structural maintenance of chromosomes protein 6	polymer	1157	132445.1	1	UniProt (Q12749) Pfam (PF13476)	Saccharomyces cerevisiae W303	DNA repair protein RHC18,Rad18 homolog
5	E (E)	Structural maintenance of chromosomes protein 5	polymer	1094	126293.2	1	UniProt (Q08204) Pfam (PF02463)	Saccharomyces cerevisiae W303
6	F (F)	Non-structural maintenance of chromosome element 3	polymer	305	34193.8	1	UniProt (Q05541) Pfam (PF01454)	Saccharomyces cerevisiae W303	Non-SMC element 3
7	G (G)	Non-structural maintenance of chromosome element 4	polymer	403	46253.0	1	UniProt (P43124) Pfam (PF15412) Pfam (PF08743)	Saccharomyces cerevisiae W303	Non-SMC element 4,Protein QRI2
8	H (E)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)

Sequence modifications

C: 1 - 336 (UniProt: A0A7I9FFW3)

PDB	External Database	Details
His 7	Gln 7	conflict
Gly 337	-	expression tag

D: 1 - 1114 (UniProt: Q12749)

PDB	External Database	Details
Gln 1048	Glu 1048	engineered mutation
Gly 1115	-	expression tag
Ser 1116	-	expression tag
Leu 1117	-	expression tag
Glu 1118	-	expression tag
Val 1119	-	expression tag
Leu 1120	-	expression tag
Phe 1121	-	expression tag
Gln 1122	-	expression tag
Gly 1123	-	expression tag
Pro 1124	-	expression tag
Gly 1125	-	expression tag
Gly 1126	-	expression tag
Ser 1127	-	expression tag
Ser 1128	-	expression tag
Ala 1129	-	expression tag
Trp 1130	-	expression tag
Ser 1131	-	expression tag
His 1132	-	expression tag
Pro 1133	-	expression tag
Gln 1134	-	expression tag
Phe 1135	-	expression tag
Glu 1136	-	expression tag
Lys 1137	-	expression tag
Gly 1138	-	expression tag
Gly 1139	-	expression tag
Gly 1140	-	expression tag
Ser 1141	-	expression tag
Gly 1142	-	expression tag
Gly 1143	-	expression tag
Gly 1144	-	expression tag
Ser 1145	-	expression tag
Gly 1146	-	expression tag
Gly 1147	-	expression tag
Gly 1148	-	expression tag
Ser 1149	-	expression tag
Trp 1150	-	expression tag
Ser 1151	-	expression tag
His 1152	-	expression tag
Pro 1153	-	expression tag
Gln 1154	-	expression tag
Phe 1155	-	expression tag
Glu 1156	-	expression tag
Lys 1157	-	expression tag

E: 1 - 1093 (UniProt: Q08204)

PDB	External Database	Details
Gln 1015	Glu 1015	engineered mutation
Gly 1094	-	expression tag

F: 1 - 303 (UniProt: Q05541)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 304	-	expression tag

G: 1 - 402 (UniProt: P43124)

PDB	External Database	Details
Gly 403	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	422557.6
Non-Polymers*	Number of molecules	1
	Total formula weight	507.2
All*	Total formula weight	423064.8

*Water molecules are not included.