7TUY
Cryo-EM structure of GSK682753A-bound EBI2/GPR183
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | anti-BRIL Fab Heavy chain | polymer | 229 | 24321.1 | 1 | Homo sapiens (Human) | ||
| 2 | B (K) | anti-Fab Nanobody | polymer | 136 | 15071.4 | 1 | synthetic construct | ||
| 3 | C (L) | anti-BRIL Fab Light chain | polymer | 215 | 23483.1 | 1 | Homo sapiens (Human) | ||
| 4 | D (R) | G-protein coupled receptor 183,Soluble cytochrome b562 fusion | polymer | 477 | 54364.5 | 1 | UniProt (P32249) Pfam (PF00001) | Homo sapiens (human) | Epstein-Barr virus-induced G-protein coupled receptor 2,EBI2,EBV-induced G-protein coupled receptor 2,hEBI2 |
| 5 | E (R) | 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | non-polymer | 479.8 | 1 | Chemie (KKF) |
Sequence modifications
R: 1 - 225 (UniProt: P32249)
R: 1001 - 1118 (PDB: 7TUY)
R: 226 - 351 (UniProt: P32249)
R: 1001 - 1118 (PDB: 7TUY)
R: 226 - 351 (UniProt: P32249)
| PDB | External Database | Details |
|---|---|---|
| Asp 352 | - | expression tag |
| Tyr 353 | - | expression tag |
| Lys 354 | - | expression tag |
| Asp 355 | - | expression tag |
| Asp 356 | - | expression tag |
| Asp 357 | - | expression tag |
| Asp 358 | - | expression tag |
| Lys 359 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117240.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 479.8 | |
| All* | Total formula weight | 117719.9 |
