7TUO
Crystal structure analysis of human USP28 complex with a compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ubiquitin carboxyl-terminal hydrolase 28 | polymer | 385 | 44972.1 | 1 | UniProt (Q96RU2) Pfam (PF00443) | Homo sapiens (human) | Deubiquitinating enzyme 28,Ubiquitin thioesterase 28,Ubiquitin-specific-processing protease 28 |
| 2 | B, C (A) | 7-amino-N-(2-{4-[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]phenyl}ethyl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide | non-polymer | 421.6 | 2 | Chemie (KL9) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E (A) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 149 - 399 (UniProt: Q96RU2)
A: 580 - 703 (UniProt: Q96RU2)
| PDB | External Database | Details |
|---|---|---|
| Ser 148 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | linker |
| Ser 401 | - | linker |
| Gly 576 | - | linker |
| Ser 577 | - | linker |
| Gly 578 | - | linker |
| Ser 579 | - | linker |
| Gln 704 | - | expression tag |
| Leu 705 | - | expression tag |
| Asn 706 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44972.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 878.6 | |
| All* | Total formula weight | 45850.7 |
