7TRE

Human telomerase catalytic core with shelterin protein TPP1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Telomerase RNA, partial sequence	polymer	451	145477.8	1	GenBank (1932797)	Homo sapiens (human)
2	A	Telomerase reverse transcriptase	polymer	1167	130711.5	1	UniProt (O14746) Pfam (PF12009) Pfam (PF00078) Pfam (PF21399) In PDB	Homo sapiens (human)	HEST2,Telomerase catalytic subunit,Telomerase-associated protein 2,TP2
3	D	Telomeric repeat substrate	polymer	18	5514.6	1		Homo sapiens
4	C	Adrenocortical dysplasia protein homolog	polymer	163	17672.6	1	UniProt (Q96AP0) Pfam (PF10341) In PDB	Homo sapiens (human)	POT1 and TIN2-interacting protein

Sequence modifications

A: 1 - 1132 (UniProt: O14746)

PDB	External Database	Details
Gly -34	-	expression tag
His -33	-	expression tag
Met -32	-	expression tag
Ser -31	-	expression tag
Ala -30	-	expression tag
Trp -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
Pro -26	-	expression tag
Gln -25	-	expression tag
Phe -24	-	expression tag
Glu -23	-	expression tag
Lys -22	-	expression tag
Gly -21	-	expression tag
Gly -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
Gly -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Ala -10	-	expression tag
Trp -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
Pro -6	-	expression tag
Gln -5	-	expression tag
Phe -4	-	expression tag
Glu -3	-	expression tag
Lys -2	-	expression tag
Ser -1	-	expression tag
Ala 0	-	expression tag

C: 88 - 249 (UniProt: Q96AP0)

PDB	External Database	Details
Gly 87	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	299376.5
All*	Total formula weight	299376.5

*Water molecules are not included.