7TQV

SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Uridylate-specific endoribonuclease	polymer	362	40697.3	6	UniProt (P0DTD1) Pfam (PF19219) Pfam (PF19216) Pfam (PF19215) In PDB	Severe acute respiratory syndrome coronavirus 2	NendoU, Non-structural protein 15, nsp15
2	G	RNA (33-MER)	polymer	52	16781.0	1		unidentified
3	H	RNA (33-MER)	polymer	52	16528.8	1		unidentified

Sequence modifications

A, B, C, D, E, F: 2 - 347 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
Met -11	-	expression tag
Leu -10	-	expression tag
Glu -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Glu 0	-	expression tag
Met 1	-	expression tag
Ala 235	His 6686	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	277493.4
All*	Total formula weight	277493.4

*Water molecules are not included.