7TPR
Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Spike glycoprotein | polymer | 1145 | 126821.5 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, E | Nanobody 8A2 | polymer | 132 | 13993.3 | 2 | Camelus dromedarius | ||
| 3 | F, G, H | Nanobody 7A3 | polymer | 125 | 13755.2 | 3 | Camelus dromedarius |
Sequence modifications
A, B, C: 15 - 1159 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 682 | Arg 682 | engineered mutation |
| Ser 683 | Arg 683 | engineered mutation |
| Ser 685 | Arg 685 | engineered mutation |
| Pro 817 | Phe 817 | engineered mutation |
| Pro 892 | Ala 892 | engineered mutation |
| Pro 899 | Ala 899 | engineered mutation |
| Pro 942 | Ala 942 | engineered mutation |
| Pro 986 | Lys 986 | engineered mutation |
| Pro 987 | Val 987 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 449716.6 | |
| All* | Total formula weight | 449716.6 |
