7TPP
Cryo-em structure of human prothrombin:prothrombinase at 4.1 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Prothrombin | polymer | 579 | 65370.1 | 1 | UniProt (P00734) Pfam (PF00051) Pfam (PF09396) Pfam (PF00089) Pfam (PF00594) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (A) | Factor X light chain | polymer | 139 | 15743.4 | 1 | UniProt (P00742) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | |
| 3 | C (C) | Coagulation factor Va | polymer | 709 | 81274.4 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 4 | D (D) | Coagulation factor Va | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | Activated protein C cofactor,Proaccelerin,labile factor |
| 5 | E (B) | Activated factor Xa heavy chain | polymer | 254 | 28534.6 | 1 | UniProt (P00742) Pfam (PF00089) | Homo sapiens (human) |
Sequence modifications
E: 1 - 579 (UniProt: P00734)
B: 195 - 448 (UniProt: P00742)
| PDB | External Database | Details |
|---|---|---|
| Ala 525 | Ser 568 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 379 | Ser 419 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 266205.5 | |
| All* | Total formula weight | 266205.5 |
