7TN0

SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	S309 light chain	polymer	214	23204.7	2		Homo sapiens
2	B, C (B, C)	S309 heavy chain	polymer	230	24573.5	2		Homo sapiens
3	E, F (E, F)	Angiotensin-converting enzyme 2	polymer	601	69620.3	2	UniProt (Q9BYF1) Pfam (PF01401)	Homo sapiens (human)
4	G, K (G, N)	S304 Fab light chain	polymer	215	23369.9	2		Homo sapiens
5	H, J (H, M)	S304 Fab heavy chain	polymer	223	23729.4	2		Homo sapiens
6	I, L (I, S)	Spike protein S1	polymer	216	24735.9	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
7	AB, M, PA, QA, T... (S, A, G, B, M...)	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
8	BB, CA, CB, DA, EB... (S, E, A, F, B...)	CHLORIDE ION	non-polymer		35.5	21	Chemie (CL)
9	AA, KA (E, F)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
10	BA, DB, EA, GA, HA... (E, S, F, I)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
11	FB, GB, HB, IB, JB... (A, B, C, D, E...)	water	water		18.0	187	Chemie (HOH)

Sequence modifications

E, F: 19 - 615 (UniProt: Q9BYF1)

PDB	External Database	Details
Leu 616	-	expression tag
Val 617	-	expression tag
Pro 618	-	expression tag
Arg 619	-	expression tag

I, S: 324 - 531 (UniProt: P0DTC2)

PDB	External Database	Details
Thr 325	Ser 325	variant
Gly 326	Ile 326	variant
Thr 327	Val 327	variant
Asp 339	Gly 339	variant
Leu 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 493	Gln 493	variant
Ser 496	Gly 496	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	378467.3
Non-Polymers*	Number of molecules	45
	Total formula weight	3991.4
All*	Total formula weight	382458.7

*Water molecules are not included.