7TL7

1.90A resolution structure of independent phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (Sa-D2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	polymer	534	58704.5	4	UniProt (G5EFZ1) Pfam (PF01676) Pfam (PF06415) In PDB	Caenorhabditis elegans	iPGM,Cofactor-independent phosphoglycerate mutase homolog
2	a, b, c, d	peptide Sa-D2	polymer	15	1863.2	4	BIRD (PRD_002491)	synthetic construct
3	A, B, C, D	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
4	A, B, C, D	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
5	C, D	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
6		water	water		18.0	1021	Chemie (HOH)

Sequence modifications

A, B, C, D: 19 - 539 (UniProt: G5EFZ1)

PDB	External Database	Details
Lys 540	-	expression tag
Leu 541	-	expression tag
Ala 542	-	expression tag
Ala 543	-	expression tag
Ala 544	-	expression tag
Leu 545	-	expression tag
Glu 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	242270.7
Non-Polymers*	Number of molecules	14
	Total formula weight	753.4
All*	Total formula weight	243024.1

*Water molecules are not included.