7TGH
Cryo-EM structure of respiratory super-complex CI+III2 from Tetrahymena thermophila
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 284 | 32636.8 | 1 | UniProt (Q950Y3) Pfam (PF00146) | Tetrahymena thermophila | |
| 2 | B (1B) | NADH dehydrogenase subunit 1 | polymer | 59 | 7238.8 | 1 | UniProt (Q09FB0) Pfam (PF00146) | Tetrahymena thermophila | |
| 3 | C (2) | Ymf65 | polymer | 360 | 43104.1 | 1 | UniProt (Q951A3) Pfam (PF00361) | Tetrahymena thermophila | |
| 4 | D (2B) | NADH dehydrogenase subunit 2 | polymer | 178 | 20899.9 | 1 | UniProt (Q951B2) Pfam (PF00361) | Tetrahymena thermophila | |
| 5 | E (3) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 121 | 14416.9 | 1 | UniProt (Q950Z7) Pfam (PF00507) | Tetrahymena thermophila | |
| 6 | F, Q (3A, 3a) | M16 family peptidase, putative | polymer | 482 | 53030.5 | 2 | UniProt (I7MJ25) Pfam (PF05193) | Tetrahymena thermophila | |
| 7 | G, R (3B, 3b) | Peptidase M16 inactive domain protein | polymer | 513 | 58023.9 | 2 | UniProt (I7MGU2) Pfam (PF00675) Pfam (PF05193) | Tetrahymena thermophila | |
| 8 | H, S (3C, 3c) | Apocytochrome b | polymer | 426 | 50635.5 | 2 | UniProt (Q950Z1) Pfam (PF00033) | Tetrahymena thermophila | |
| 9 | I, T (3D, 3d) | Cytochrome protein c1 | polymer | 319 | 37616.6 | 2 | UniProt (Q24IM5) Pfam (PF02167) | Tetrahymena thermophila | |
| 10 | J, U (3E, 3e) | Rieske iron-sulfur protein, ubiquinol-cytochrome C reductase iron-sulfur subunit | polymer | 269 | 30697.0 | 2 | UniProt (I7MIC7) Pfam (PF00355) | Tetrahymena thermophila | |
| 11 | K, V (3F, 3f) | Ubiquinol-cytochrome C reductase hinge protein | polymer | 90 | 10250.0 | 2 | UniProt (Q22AX2) Pfam (PF02320) | Tetrahymena thermophila | |
| 12 | L, W (3G, 3g) | UQCRB | polymer | 328 | 39193.5 | 2 | UniProt (Q23F81) | Tetrahymena thermophila | |
| 13 | M, X (3H, 3h) | Transmembrane protein, putative | polymer | 130 | 15677.8 | 2 | UniProt (I7M484) | Tetrahymena thermophila | |
| 14 | N, Y (3I, 3i) | Transmembrane protein, putative | polymer | 119 | 14262.6 | 2 | UniProt (I7MM45) | Tetrahymena thermophila | |
| 15 | O, Z (3J, 3j) | Transmembrane protein, putative | polymer | 62 | 7455.7 | 2 | UniProt (I7MFL6) | Tetrahymena thermophila | |
| 16 | P (3M) | UNK1 | polymer | 19 | 2181.6 | 1 | Tetrahymena thermophila | ||
| 17 | AA (3l) | UNK2 | polymer | 24 | 1781.9 | 1 | Tetrahymena thermophila | ||
| 18 | BA (3m) | UNK3 | polymer | 17 | 1725.0 | 1 | Tetrahymena thermophila | ||
| 19 | CA (4) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 505 | 58690.0 | 1 | UniProt (Q950X9) Pfam (PF00361) | Tetrahymena thermophila | |
| 20 | DA (4L) | Ymf58 | polymer | 116 | 13509.9 | 1 | UniProt (Q950Z5) | Tetrahymena thermophila | |
| 21 | EA (5) | NADH dehydrogenase subunit 5 | polymer | 750 | 88179.8 | 1 | UniProt (Q950Z0) Pfam (PF00361) | Tetrahymena thermophila | |
| 22 | FA (5B) | Ymf57 | polymer | 100 | 12473.9 | 1 | UniProt (Q951C2) | Tetrahymena thermophila | |
| 23 | GA (6) | Ymf62 | polymer | 255 | 30448.5 | 1 | UniProt (Q950Y2) | Tetrahymena thermophila | |
| 24 | HA (A2) | Ribosomal protein L51/S25/CI-B8 domain protein | polymer | 103 | 12157.8 | 1 | UniProt (I7MA77) Pfam (PF05047) | Tetrahymena thermophila | |
| 25 | IA (A5) | ETC complex I subunit motif protein | polymer | 206 | 24277.9 | 1 | UniProt (Q23ND5) Pfam (PF04716) | Tetrahymena thermophila | |
| 26 | JA (A6) | NADH dehydrogenase, putative | polymer | 172 | 20167.9 | 1 | UniProt (I7M2Y3) | Tetrahymena thermophila | |
| 27 | KA (A7) | NDUA7 | polymer | 282 | 33201.8 | 1 | UniProt (I7MIJ7) | Tetrahymena thermophila | |
| 28 | LA (A9) | NAD-dependent epimerase/dehydratase family protein | polymer | 362 | 41375.1 | 1 | UniProt (I7MLH2) Pfam (PF01370) | Tetrahymena thermophila | |
| 29 | MA (AB) | Acyl carrier protein | polymer | 138 | 16249.4 | 1 | UniProt (Q22XT6) Pfam (PF00550) | Tetrahymena thermophila | |
| 30 | NA (AC) | Acyl carrier protein | polymer | 133 | 15428.4 | 1 | UniProt (I7MD12) Pfam (PF00550) | Tetrahymena thermophila | |
| 31 | OA (AL) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 194 | 22890.6 | 1 | UniProt (A4VDQ6) Pfam (PF05071) | Tetrahymena thermophila | |
| 32 | PA (AM) | NDUA13 | polymer | 175 | 21045.6 | 1 | UniProt (I7M2U4) | Tetrahymena thermophila | |
| 33 | QA (B7) | NDUB7 | polymer | 120 | 13747.4 | 1 | UniProt (I7MIM0) | Tetrahymena thermophila | |
| 34 | RA (B8) | NDUB8 | polymer | 207 | 24150.5 | 1 | UniProt (I7M855) | Tetrahymena thermophila | |
| 35 | SA (BL) | NDUB10 | polymer | 188 | 22167.1 | 1 | UniProt (Q23KG0) | Tetrahymena thermophila | |
| 36 | TA (C) | UNK4 | polymer | 209 | 17804.9 | 1 | Tetrahymena thermophila | ||
| 37 | UA (C1) | Gamma-carbonic anhydrase | polymer | 257 | 28216.7 | 1 | UniProt (Q22XU5) Pfam (PF00132) | Tetrahymena thermophila | |
| 38 | VA (C2) | Gamma-carbonic anhydrase | polymer | 233 | 25396.0 | 1 | UniProt (I7M6S0) Pfam (PF21711) | Tetrahymena thermophila | |
| 39 | WA (C3) | Transcription factor apfi protein, putative | polymer | 346 | 39793.4 | 1 | UniProt (I7M8Q7) Pfam (PF00132) | Tetrahymena thermophila | |
| 40 | XA (TD) | Transmembrane protein, putative | polymer | 73 | 8787.1 | 1 | UniProt (Q22DC2) | Tetrahymena thermophila | |
| 41 | YA (J1) | DnaJ domain protein | polymer | 317 | 36878.4 | 1 | UniProt (Q22DR7) Pfam (PF00226) | Tetrahymena thermophila | |
| 42 | ZA (FX) | 2 iron, 2 sulfur cluster-binding protein | polymer | 172 | 19564.2 | 1 | UniProt (Q22W11) Pfam (PF00111) | Tetrahymena thermophila | |
| 43 | AB (T2) | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II | polymer | 333 | 36709.4 | 1 | UniProt (Q24HK5) Pfam (PF00501) | Tetrahymena thermophila | |
| 44 | BB (T1) | Lipid-A-disaccharide synthase | polymer | 516 | 59307.3 | 1 | UniProt (Q22E24) Pfam (PF02684) | Tetrahymena thermophila | |
| 45 | CB (A1) | NDUA1 | polymer | 94 | 11451.2 | 1 | UniProt (I7MI60) | Tetrahymena thermophila | |
| 46 | DB (X1) | NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit | polymer | 150 | 17381.8 | 1 | UniProt (I7LT42) Pfam (PF10785) | Tetrahymena thermophila | |
| 47 | EB (T6) | NDUTT6 | polymer | 144 | 17078.3 | 1 | UniProt (I7M1N8) | Tetrahymena thermophila | |
| 48 | FB (T5) | Transmembrane protein, putative | polymer | 205 | 23971.0 | 1 | UniProt (I7LT77) | Tetrahymena thermophila | |
| 49 | GB (R) | UNK5 | polymer | 124 | 13356.4 | 1 | Tetrahymena thermophila | ||
| 50 | HB (S1) | NADH-ubiquinone oxidoreductase 75 kDa subunit | polymer | 718 | 80580.8 | 1 | UniProt (Q23KA9) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) | Tetrahymena thermophila | |
| 51 | IB (S2) | NADH dehydrogenase subunit 7 | polymer | 442 | 51227.5 | 1 | UniProt (Q951B1) Pfam (PF00346) | Tetrahymena thermophila | |
| 52 | JB (S3) | NADH dehydrogenase subunit 9 | polymer | 198 | 23803.3 | 1 | UniProt (Q950Z4) Pfam (PF00329) | Tetrahymena thermophila | |
| 53 | KB (S4) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 185 | 21642.4 | 1 | UniProt (I7MK61) Pfam (PF04800) | Tetrahymena thermophila | |
| 54 | LB (S6) | Zinc-finger protein | polymer | 132 | 15141.3 | 1 | UniProt (I7MK02) Pfam (PF10276) | Tetrahymena thermophila | |
| 55 | MB (S7) | NADH dehydrogenase subunit 10 | polymer | 162 | 18324.3 | 1 | UniProt (Q951B4) Pfam (PF01058) | Tetrahymena thermophila | |
| 56 | NB (S8) | NADH-ubiquinone oxidoreductase 1, chain, putative | polymer | 236 | 28053.5 | 1 | UniProt (I7MDW5) Pfam (PF12838) | Tetrahymena thermophila | |
| 57 | OB (B9) | NDUB9 | polymer | 189 | 22698.3 | 1 | UniProt (Q233X7) | Tetrahymena thermophila | |
| 58 | PB (TX) | Thioredoxin | polymer | 166 | 19540.2 | 1 | UniProt (Q22AI5) Pfam (PF00085) | Tetrahymena thermophila | |
| 59 | QB (A8) | NDUA8 | polymer | 238 | 28412.8 | 1 | UniProt (I7MMF4) | Tetrahymena thermophila | |
| 60 | RB (TB) | Transmembrane protein, putative | polymer | 113 | 13341.0 | 1 | UniProt (Q22T55) | Tetrahymena thermophila | |
| 61 | SB (V1) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 474 | 52313.7 | 1 | UniProt (Q23KE4) Pfam (PF01512) Pfam (PF22461) Pfam (PF10531) Pfam (PF10589) | Tetrahymena thermophila | |
| 62 | TB (V2) | NADH-ubiquinone oxidoreductase 24 kDa subunit | polymer | 274 | 31216.7 | 1 | UniProt (I7MEP0) Pfam (PF01257) | Tetrahymena thermophila | |
| 63 | UB (B6) | NDUB6 | polymer | 129 | 15444.3 | 1 | UniProt (Q231G0) | Tetrahymena thermophila | |
| 64 | VB (BM) | Transmembrane protein, putative | polymer | 214 | 24419.2 | 1 | UniProt (Q22Z32) | Tetrahymena thermophila | |
| 65 | WB (C4) | NDUC2 | polymer | 102 | 12103.0 | 1 | UniProt (Q22W63) | Tetrahymena thermophila | |
| 66 | XB (AN) | Transmembrane protein, putative | polymer | 231 | 26545.1 | 1 | UniProt (Q24F24) | Tetrahymena thermophila | |
| 67 | YB (B4) | NDUB4 | polymer | 108 | 12578.0 | 1 | Tetrahymena thermophila | ||
| 68 | ZB (T4) | NDUTT4 | polymer | 212 | 24823.3 | 1 | UniProt (I7MIE0) | Tetrahymena thermophila | |
| 69 | AC (T8) | NDUTT8 | polymer | 135 | 15785.2 | 1 | UniProt (Q22SC4) | Tetrahymena thermophila | |
| 70 | BC (B2) | NDUB2 | polymer | 126 | 14410.4 | 1 | UniProt (I7MG29) | Tetrahymena thermophila | |
| 71 | CC (T3) | NDUTT3 | polymer | 311 | 35409.2 | 1 | UniProt (I7LUQ4) | Tetrahymena thermophila | |
| 72 | DC (P1) | Transmembrane protein, putative | polymer | 251 | 29389.7 | 1 | UniProt (Q24C39) | Tetrahymena thermophila | |
| 73 | EC (B3) | Transmembrane protein, putative | polymer | 83 | 9942.4 | 1 | UniProt (A4VD20) | Tetrahymena thermophila | |
| 74 | FC (TA) | NDUTT10 | polymer | 102 | 12123.9 | 1 | UniProt (I7MAF0) | Tetrahymena thermophila | |
| 75 | GC (S5) | GRAM domain protein | polymer | 94 | 10920.4 | 1 | UniProt (W7X4R4) | Tetrahymena thermophila | |
| 76 | HC (TC) | NDUTT12 | polymer | 93 | 11283.5 | 1 | UniProt (Q22E95) | Tetrahymena thermophila | |
| 77 | IC (P2) | NDUPH2 | polymer | 189 | 22446.6 | 1 | UniProt (Q23KE0) | Tetrahymena thermophila | |
| 78 | JC (A3) | Transmembrane protein, putative | polymer | 135 | 15831.7 | 1 | UniProt (I7M9B3) | Tetrahymena thermophila | |
| 79 | KC (T9) | NDUTT9 | polymer | 135 | 15576.6 | 1 | UniProt (Q23B10) | Tetrahymena thermophila | |
| 80 | LC (TE) | Transmembrane protein, putative | polymer | 71 | 8445.9 | 1 | UniProt (I7MIK1) | Tetrahymena thermophila | |
| 81 | MC (T7) | Transmembrane protein, putative | polymer | 143 | 16909.2 | 1 | UniProt (Q22HE4) | Tetrahymena thermophila | |
| 82 | AF, BG, CE, CG, EF... (TD, AN, 3i, B4, T1...) | CARDIOLIPIN | non-polymer | 1464.0 | 29 | Chemie (CDL) | |||
| 83 | AE, AG, BE, BF, CD... (3e, AN, 3g, J1, 3E...) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 32 | Chemie (PC1) | |||
| 84 | TC, TD, UC, UD (3C, 3c) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 85 | ID, OE, XC (3H, 5B, 3C) | UBIQUINONE-10 | non-polymer | 863.3 | 3 | Chemie (U10) | |||
| 86 | AD, YD (3D, 3d) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 87 | BD, CF, KF, SF (3E, FX, S1, V2) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 88 | DD, DG, EE, EG, FE... (3E, T4, 4, T8, P1...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 17 | Chemie (3PE) | |||
| 89 | FD, LF, SE (3F, S6, A9) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 90 | RE (A9) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 91 | TE (AB) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 1 | Chemie (ZMP) | |||
| 92 | YE (B8) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 93 | IF, JF, MF, NF, OF... (S1, S7, S8, V1) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 94 | RF (V1) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) |
Sequence modifications
1B: 1 - 59 (UniProt: Q09FB0)
| PDB | External Database | Details |
|---|---|---|
| Val 49 | Leu 49 | conflict |
| Thr 56 | Ser 56 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 91 |
| Total formula weight | 2324212.6 | |
| Non-Polymers* | Number of molecules | 104 |
| Total formula weight | 91959.0 | |
| All* | Total formula weight | 2416171.6 |
