Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7TGH

Cryo-EM structure of respiratory super-complex CI+III2 from Tetrahymena thermophila

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005739	cellular_component	mitochondrion
1	0005743	cellular_component	mitochondrial inner membrane
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0016020	cellular_component	membrane
1	0016491	molecular_function	oxidoreductase activity
1	1902600	biological_process	proton transmembrane transport
1B	0005739	cellular_component	mitochondrion
1B	0016020	cellular_component	membrane
2	0005739	cellular_component	mitochondrion
2	0016020	cellular_component	membrane
2B	0005739	cellular_component	mitochondrion
2B	0016020	cellular_component	membrane
2B	0016491	molecular_function	oxidoreductase activity
3	0005739	cellular_component	mitochondrion
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0016491	molecular_function	oxidoreductase activity
3	0030964	cellular_component	NADH dehydrogenase complex
3	0031966	cellular_component	mitochondrial membrane
3	0070469	cellular_component	respirasome
3	1902600	biological_process	proton transmembrane transport
3a	0005739	cellular_component	mitochondrion
3a	0046872	molecular_function	metal ion binding
3A	0005739	cellular_component	mitochondrion
3A	0046872	molecular_function	metal ion binding
3b	0005739	cellular_component	mitochondrion
3b	0046872	molecular_function	metal ion binding
3B	0005739	cellular_component	mitochondrion
3B	0046872	molecular_function	metal ion binding
3c	0005739	cellular_component	mitochondrion
3c	0009055	molecular_function	electron transfer activity
3c	0016020	cellular_component	membrane
3c	0016491	molecular_function	oxidoreductase activity
3c	0022904	biological_process	respiratory electron transport chain
3C	0005739	cellular_component	mitochondrion
3C	0009055	molecular_function	electron transfer activity
3C	0016020	cellular_component	membrane
3C	0016491	molecular_function	oxidoreductase activity
3C	0022904	biological_process	respiratory electron transport chain
3d	0005750	cellular_component	mitochondrial respiratory chain complex III
3d	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
3d	0009055	molecular_function	electron transfer activity
3d	0016020	cellular_component	membrane
3d	0020037	molecular_function	heme binding
3d	0046872	molecular_function	metal ion binding
3D	0005750	cellular_component	mitochondrial respiratory chain complex III
3D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
3D	0009055	molecular_function	electron transfer activity
3D	0016020	cellular_component	membrane
3D	0020037	molecular_function	heme binding
3D	0046872	molecular_function	metal ion binding
3e	0005750	cellular_component	mitochondrial respiratory chain complex III
3e	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
3e	0016020	cellular_component	membrane
3e	0016491	molecular_function	oxidoreductase activity
3e	0046872	molecular_function	metal ion binding
3e	0051537	molecular_function	2 iron, 2 sulfur cluster binding
3E	0005750	cellular_component	mitochondrial respiratory chain complex III
3E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
3E	0016020	cellular_component	membrane
3E	0016491	molecular_function	oxidoreductase activity
3E	0046872	molecular_function	metal ion binding
3E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
3f	0005739	cellular_component	mitochondrion
3f	0005743	cellular_component	mitochondrial inner membrane
3f	0070469	cellular_component	respirasome
3F	0005739	cellular_component	mitochondrion
3F	0005743	cellular_component	mitochondrial inner membrane
3F	0070469	cellular_component	respirasome
3i	0016020	cellular_component	membrane
3I	0016020	cellular_component	membrane
3j	0016020	cellular_component	membrane
3J	0016020	cellular_component	membrane
4	0005739	cellular_component	mitochondrion
4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4	0016020	cellular_component	membrane
4	0016491	molecular_function	oxidoreductase activity
4	0031966	cellular_component	mitochondrial membrane
4	0042773	biological_process	ATP synthesis coupled electron transport
4	0070469	cellular_component	respirasome
4	1902600	biological_process	proton transmembrane transport
4L	0005739	cellular_component	mitochondrion
4L	0016020	cellular_component	membrane
5	0003954	molecular_function	NADH dehydrogenase activity
5	0005739	cellular_component	mitochondrion
5	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0015990	biological_process	electron transport coupled proton transport
5	0016020	cellular_component	membrane
5	0016491	molecular_function	oxidoreductase activity
5	0042773	biological_process	ATP synthesis coupled electron transport
5B	0005739	cellular_component	mitochondrion
5B	0016020	cellular_component	membrane
6	0005739	cellular_component	mitochondrion
6	0016020	cellular_component	membrane
A1	0016020	cellular_component	membrane
A2	0005739	cellular_component	mitochondrion
A2	0005743	cellular_component	mitochondrial inner membrane
A2	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A2	0005840	cellular_component	ribosome
A2	0070469	cellular_component	respirasome
A3	0016020	cellular_component	membrane
A5	0005739	cellular_component	mitochondrion
A5	0005743	cellular_component	mitochondrial inner membrane
A5	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A5	0022904	biological_process	respiratory electron transport chain
A6	0005739	cellular_component	mitochondrion
A6	0005743	cellular_component	mitochondrial inner membrane
A6	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A6	0006979	biological_process	response to oxidative stress
A6	0070469	cellular_component	respirasome
A9	0005739	cellular_component	mitochondrion
A9	0044877	molecular_function	protein-containing complex binding
A9	1901006	biological_process	ubiquinone-6 biosynthetic process
AB	0000035	molecular_function	acyl binding
AB	0000036	molecular_function	acyl carrier activity
AB	0005739	cellular_component	mitochondrion
AB	0006633	biological_process	fatty acid biosynthetic process
AC	0000035	molecular_function	acyl binding
AC	0000036	molecular_function	acyl carrier activity
AC	0005739	cellular_component	mitochondrion
AC	0006633	biological_process	fatty acid biosynthetic process
AL	0005739	cellular_component	mitochondrion
AL	0005743	cellular_component	mitochondrial inner membrane
AL	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
AL	0006979	biological_process	response to oxidative stress
AL	0016020	cellular_component	membrane
AL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AL	0070469	cellular_component	respirasome
AN	0016020	cellular_component	membrane
BM	0016020	cellular_component	membrane
FX	0051536	molecular_function	iron-sulfur cluster binding
FX	0051537	molecular_function	2 iron, 2 sulfur cluster binding
FX	0140647	biological_process	P450-containing electron transport chain
P1	0016020	cellular_component	membrane
S1	0003954	molecular_function	NADH dehydrogenase activity
S1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S1	0016020	cellular_component	membrane
S1	0016491	molecular_function	oxidoreductase activity
S1	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S1	0042773	biological_process	ATP synthesis coupled electron transport
S1	0045333	biological_process	cellular respiration
S1	0046872	molecular_function	metal ion binding
S1	0051536	molecular_function	iron-sulfur cluster binding
S1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S1	1902600	biological_process	proton transmembrane transport
S2	0005739	cellular_component	mitochondrion
S2	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
S2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S2	0016491	molecular_function	oxidoreductase activity
S2	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S2	0048038	molecular_function	quinone binding
S2	0051287	molecular_function	NAD binding
S3	0005739	cellular_component	mitochondrion
S3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S3	0016491	molecular_function	oxidoreductase activity
S3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S3	1902600	biological_process	proton transmembrane transport
S4	0005739	cellular_component	mitochondrion
S4	0005743	cellular_component	mitochondrial inner membrane
S4	0022900	biological_process	electron transport chain
S4	0070469	cellular_component	respirasome
S6	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
S6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S7	0005739	cellular_component	mitochondrion
S7	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S7	0009060	biological_process	aerobic respiration
S7	0015990	biological_process	electron transport coupled proton transport
S7	0016491	molecular_function	oxidoreductase activity
S7	0046872	molecular_function	metal ion binding
S7	0048038	molecular_function	quinone binding
S7	0051536	molecular_function	iron-sulfur cluster binding
S7	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S8	0003954	molecular_function	NADH dehydrogenase activity
S8	0005739	cellular_component	mitochondrion
S8	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
S8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S8	0016020	cellular_component	membrane
S8	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S8	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S8	0051539	molecular_function	4 iron, 4 sulfur cluster binding
T1	0005543	molecular_function	phospholipid binding
T1	0008915	molecular_function	lipid-A-disaccharide synthase activity
T1	0009245	biological_process	lipid A biosynthetic process
T1	0016757	molecular_function	glycosyltransferase activity
T2	0006631	biological_process	fatty acid metabolic process
T2	0016874	molecular_function	ligase activity
T2	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
T5	0016020	cellular_component	membrane
T7	0016020	cellular_component	membrane
TB	0016020	cellular_component	membrane
TD	0016020	cellular_component	membrane
TE	0016020	cellular_component	membrane
V1	0005739	cellular_component	mitochondrion
V1	0005743	cellular_component	mitochondrial inner membrane
V1	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
V1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
V1	0010181	molecular_function	FMN binding
V1	0045271	cellular_component	respiratory chain complex I
V1	0046872	molecular_function	metal ion binding
V1	0051287	molecular_function	NAD binding
V1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V1	0070469	cellular_component	respirasome
V1	1902600	biological_process	proton transmembrane transport
V2	0003954	molecular_function	NADH dehydrogenase activity
V2	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
V2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V2	0016491	molecular_function	oxidoreductase activity
V2	0045271	cellular_component	respiratory chain complex I
V2	0046872	molecular_function	metal ion binding
V2	0051537	molecular_function	2 iron, 2 sulfur cluster binding
X1	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KLGLDSLDQTALLASI

Chain	Residue	Details
AB	LYS90-ILE105

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCQsACP

Chain	Residue	Details
S8	CYS136-PRO147
S8	CYS175-PRO186

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGsEKLiEdR

Chain	Residue	Details
S2	LEU62-ARG73

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtsEMYginykwKidtRkLL

Chain	Residue	Details
S3	GLU136-LEU157

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
S1	PRO62-CYS79

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
S1	CYS129-GLN141

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
S1	ARG176-PHE186

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
V1	GLU378-GLY389

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GRLQyIaDALKLFiKG

Chain	Residue	Details
1	GLY63-GLY78

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEAEseLVt.G

Chain	Residue	Details
1	PRO218-GLY231

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)