7TFN
Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Envelope glycoprotein BG505 SOSIP.664 - gp120 | polymer | 481 | 54064.3 | 3 | UniProt (A0A6H1VH54) Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6) In PDB | Human immunodeficiency virus 1 | |
2 | H, I, P | Anti-HIV-1 CD4bs antibody Fab Ab1303 - Heavy chain | polymer | 235 | 25338.2 | 3 | Macaca mulatta (Rhesus monkey) | ||
3 | J, L, Q | CD4 binding site antibody Fab Ab1303 - light chain | polymer | 217 | 23420.0 | 3 | Macaca mulatta (Rhesus monkey) | ||
4 | X, Y, Z | Envelope glycoprotein BG505 SOSIP.664 - gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
5 | D | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
6 | b, c, E, O | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
7 | F, N, R, T, V... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
8 | G | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
9 | M, S, U, W | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 4 | In PDB GlyTouCan (G81315DD) | |||
10 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
11 | C | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) |
Sequence modifications
A, B, C: 31 - 511 (UniProt: A0A6H1VH54)
X, Y, Z: 512 - 664 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Lys 64 | Glu 63 | conflict |
Ser 375 | Tyr 373 | conflict |
Cys 501 | Ala 498 | conflict |
Arg 509 | Glu 506 | conflict |
Arg 512 | - | expression tag |
Arg 513 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | conflict |
Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 359906.9 | |
Branched | Number of molecules | 16 |
Total formula weight | 9546.8 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1949.8 | |
All* | Total formula weight | 371403.6 |