7TD2

Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	Lysophosphatidic acid receptor 1	polymer	350	39734.6	1	UniProt (Q92633) Pfam (PF00001)	Homo sapiens (human)	LPA receptor 1,LPA-1,Lysophosphatidic acid receptor Edg-2
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37416.9	1	UniProt (P62871) Pfam (PF00400)	Bos taurus (cattle)	Transducin beta chain 1
3	C (A)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	379	43163.1	1	UniProt (B2RSH2) Pfam (PF00503) UniProt (by SIFTS) (P10824)	Rattus norvegicus (Norway rat)	Adenylate cyclase-inhibiting G alpha protein
4	D (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7845.1	1	UniProt (P63212) Pfam (PF00631)	Bos taurus (cattle)	G gamma-I
5	E (R)	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate	non-polymer		436.5	1	Chemie (NKP)

Sequence modifications

R: 2 - 340 (UniProt: Q92633)

PDB	External Database	Details
Asp -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Lys -2	-	expression tag
Ala -1	-	expression tag
Ala 0	-	expression tag
Ala 1	-	expression tag

A: 1 - 354 (UniProt: B2RSH2)

PDB	External Database	Details
Met -24	-	initiating methionine
Gly -23	-	expression tag
Ser -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Leu -11	-	expression tag
Glu -10	-	expression tag
Val -9	-	expression tag
Leu -8	-	expression tag
Phe -7	-	expression tag
Gln -6	-	expression tag
Gly -5	-	expression tag
Pro -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Ala 203	Gly 203	engineered mutation

G: 1 - 71 (UniProt: P63212)

PDB	External Database	Details
Ser 68	Cys 68	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	128159.7
Non-Polymers*	Number of molecules	1
	Total formula weight	436.5
All*	Total formula weight	128596.2

*Water molecules are not included.