Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7TD2

Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0032794molecular_functionGTPase activating protein binding
A0032991cellular_componentprotein-containing complex
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0050805biological_processnegative regulation of synaptic transmission
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001965molecular_functionG-protein alpha-subunit binding
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005543molecular_functionphospholipid binding
R0005737cellular_componentcytoplasm
R0005768cellular_componentendosome
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007202biological_processobsolete activation of phospholipase C activity
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0008289molecular_functionlipid binding
R0008360biological_processregulation of cell shape
R0009986cellular_componentcell surface
R0010977biological_processnegative regulation of neuron projection development
R0014003biological_processoligodendrocyte development
R0016020cellular_componentmembrane
R0019222biological_processregulation of metabolic process
R0021549biological_processcerebellum development
R0021554biological_processoptic nerve development
R0022008biological_processneurogenesis
R0022038biological_processcorpus callosum development
R0030139cellular_componentendocytic vesicle
R0030165molecular_functionPDZ domain binding
R0032060biological_processbleb assembly
R0035025biological_processpositive regulation of Rho protein signal transduction
R0035727molecular_functionlysophosphatidic acid binding
R0042552biological_processmyelination
R0042734cellular_componentpresynaptic membrane
R0043025cellular_componentneuronal cell body
R0043065biological_processpositive regulation of apoptotic process
R0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
R0043197cellular_componentdendritic spine
R0043198cellular_componentdendritic shaft
R0043410biological_processpositive regulation of MAPK cascade
R0043951biological_processnegative regulation of cAMP-mediated signaling
R0045211cellular_componentpostsynaptic membrane
R0051496biological_processpositive regulation of stress fiber assembly
R0060326biological_processcell chemotaxis
R0060999biological_processpositive regulation of dendritic spine development
R0070915molecular_functionlysophosphatidic acid receptor activity
R0071453biological_processcellular response to oxygen levels
R0071673biological_processpositive regulation of smooth muscle cell chemotaxis
R0098693biological_processregulation of synaptic vesicle cycle
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099004biological_processobsolete calmodulin dependent kinase signaling pathway
R0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
R1902018biological_processnegative regulation of cilium assembly
R1904566biological_processcellular response to 1-oleoyl-sn-glycerol 3-phosphate
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVaNLLAIAIERHItV
ChainResidueDetails
RALA134-VAL150

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7626050
ChainResidueDetails
GALA2
ALEU175
AASP200
AASN269

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:1903391
ChainResidueDetails
GSER68
RGLU145-ARG163
RALA226-SER255

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050
ChainResidueDetails
GSER68

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:19703466, ECO:0000269|PubMed:25037222, ECO:0000269|PubMed:9705312, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:4PAO
ChainResidueDetails
ATHR181
RGLY185-ASP204
RASP281-LYS294

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ
ChainResidueDetails
AALA326

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:26253820
ChainResidueDetails
AGLY2

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:26253820
ChainResidueDetails
ACYS3

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
RLEU256-LEU280

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
RPHE295-ASP315

site_idSWS_FT_FI10
Number of Residues3
DetailsBINDING: BINDING => ECO:0000305|PubMed:26091040
ChainResidueDetails
RLYS39
RARG124
RTRP210

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN27
RASN35

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 533
ChainResidueDetails
AGLU43electrostatic stabiliser
ATHR48electrostatic stabiliser
AARG178electrostatic stabiliser
AASP200electrostatic stabiliser
AGLN204electrostatic stabiliser

222036

PDB entries from 2024-07-03

PDB statisticsPDBj update infoContact PDBjnumon