7T6U

Structure of the human FPR2-Gi complex with CGEN-855A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	353	40313.9	1	UniProt (P63096) Pfam (PF00503) In PDB	Homo sapiens (Human)	Adenylate cyclase-inhibiting G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	353	39021.6	1	UniProt (P54311) Pfam (PF00400) In PDB	Rattus	Transducin beta chain 1
3	C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	67	7432.6	1	UniProt (P63212) Pfam (PF00631) In PDB	Bos taurus (Cattle)	G gamma-I
4	E	B9-scFv	polymer	247	26323.3	1		Rattus
5	L	Synthetic peptide	polymer	8	1074.3	1		Homo
6	R	N-formyl peptide receptor 2	polymer	390	43246.3	1	UniProt (P25090) Pfam (PF00001) In PDB	Homo sapiens (Human)	FMLP-related receptor I,FMLP-R-I,Formyl peptide receptor-like 1,HM63,Lipoxin A4 receptor,LXA4 receptor,RFP
7	R	PALMITIC ACID	non-polymer		256.4	2	Chemie (PLM)

Sequence modifications

A: 2 - 354 (UniProt: P63096)

PDB	External Database	Details
Ala 203	Gly 203	conflict
Ser 326	Ala 326	conflict

B: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Glu 6	Gln 6	conflict

R: 1 - 342 (UniProt: P25090)

PDB	External Database	Details
Asp -47	-	expression tag
Tyr -46	-	expression tag
Lys -45	-	expression tag
Asp -44	-	expression tag
Asp -43	-	expression tag
Asp -42	-	expression tag
Asp -41	-	expression tag
Val -40	-	expression tag
Asp -39	-	expression tag
Met -38	-	expression tag
Gly -37	-	expression tag
Gln -36	-	expression tag
Pro -35	-	expression tag
Gly -34	-	expression tag
Asn -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
Ala -30	-	expression tag
Phe -29	-	expression tag
Leu -28	-	expression tag
Leu -27	-	expression tag
Ala -26	-	expression tag
Pro -25	-	expression tag
Asn -24	-	expression tag
Gly -23	-	expression tag
Ser -22	-	expression tag
His -21	-	expression tag
Ala -20	-	expression tag
Pro -19	-	expression tag
Asp -18	-	expression tag
His -17	-	expression tag
Asp -16	-	expression tag
Val -15	-	expression tag
Thr -14	-	expression tag
Gln -13	-	expression tag
Gln -12	-	expression tag
Arg -11	-	expression tag
Asp -10	-	expression tag
Glu -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	157412.0
Non-Polymers*	Number of molecules	2
	Total formula weight	512.8
All*	Total formula weight	157924.8

*Water molecules are not included.