7T5Q
Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Actin-related protein 3 | polymer | 418 | 47428.0 | 1 | UniProt (P61157) Pfam (PF00022) | Bos taurus (cattle) | Actin-2,Actin-like protein 3 |
| 2 | B (B) | Actin-related protein 2 | polymer | 394 | 44818.7 | 1 | UniProt (A7MB62) Pfam (PF00022) | Bos taurus (cattle) | Actin-like protein 2 |
| 3 | C (C) | Actin-related protein 2/3 complex subunit 1A | polymer | 370 | 41594.2 | 1 | UniProt (Q1JP79) Pfam (PF00400) | Bos taurus (cattle) | |
| 4 | D (D) | Actin-related protein 2/3 complex subunit 2 | polymer | 300 | 34402.0 | 1 | UniProt (Q3MHR7) Pfam (PF04045) | Bos taurus (cattle) | Arp2/3 complex 34 kDa subunit,p34-ARC |
| 5 | E (E) | Actin-related protein 2/3 complex subunit 3 | polymer | 178 | 20572.7 | 1 | UniProt (Q3T035) Pfam (PF04062) | Bos taurus (cattle) | Arp2/3 complex 21 kDa subunit,p21-ARC |
| 6 | F (F) | Actin-related protein 2/3 complex subunit 4 | polymer | 168 | 19697.0 | 1 | UniProt (Q148J6) Pfam (PF05856) | Bos taurus (cattle) | Arp2/3 complex 20 kDa subunit,p20-ARC |
| 7 | G (G) | Actin-related protein 2/3 complex subunit 5 | polymer | 151 | 16251.3 | 1 | UniProt (Q3SYX9) Pfam (PF04699) | Bos taurus (cattle) | Arp2/3 complex 16 kDa subunit,p16-ARC |
| 8 | H (H) | Actin, alpha skeletal muscle | polymer | 375 | 41875.6 | 1 | UniProt (P68135) Pfam (PF00022) | Oryctolagus cuniculus (rabbit) | Alpha-actin-1 |
| 9 | I (I) | F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera | polymer | 346 | 39600.6 | 1 | UniProt (Q91YD9) UniProt (P52907) Pfam (PF01267) Pfam (PF02205) | Homo sapiens (human) | CapZ alpha-1,Neural Wiskott-Aldrich syndrome protein,N-WASP |
| 10 | J (J) | F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera | polymer | 333 | 37470.8 | 1 | UniProt (P47756) UniProt (Q91YD9) Pfam (PF01115) Pfam (PF02205) | Homo sapiens (human) | CapZ beta,Neural Wiskott-Aldrich syndrome protein,N-WASP |
| 11 | K, M, P (A, B, H) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 12 | L, N (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 13 | O (H) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
I: 1 - 280 (UniProt: P52907)
I: 281 - 346 (UniProt: Q91YD9)
J: 1 - 271 (UniProt: P47756)
J: 272 - 333 (UniProt: Q91YD9)
I: 281 - 346 (UniProt: Q91YD9)
J: 1 - 271 (UniProt: P47756)
J: 272 - 333 (UniProt: Q91YD9)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 343711.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1514.5 | |
| All* | Total formula weight | 345225.5 |
