登録情報 データベース : EMDB / ID : EMD-25707 ダウンロードとリンクタイトル Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation マップデータMain map post processed with deepEMhancer 詳細 試料複合体 : bovine Arp2/3 complex and Actin, CapZ複合体 : bovine Arp2/3複合体 : Actin skeletal muscle複合体 : F-actin-capping proteinリガンド : x 3種 詳細 キーワード actin / ATPase / actin related protein / arp / cytoskeleton / Arp2-3 complex / actin nucleation / actin branching / CONTRACTILE PROTEIN / CapZ機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of membrane tubulation / spindle localization / membrane invagination / positive regulation of clathrin-dependent endocytosis / EPHB-mediated forward signaling / Regulation of actin dynamics for phagocytic cup formation / RHO GTPases Activate WASPs and WAVEs / plasma membrane tubulation / Arp2/3 protein complex / negative regulation of lymphocyte migration ... negative regulation of membrane tubulation / spindle localization / membrane invagination / positive regulation of clathrin-dependent endocytosis / EPHB-mediated forward signaling / Regulation of actin dynamics for phagocytic cup formation / RHO GTPases Activate WASPs and WAVEs / plasma membrane tubulation / Arp2/3 protein complex / negative regulation of lymphocyte migration / Arp2/3 complex-mediated actin nucleation / postsynapse organization / WASH complex / : / actin nucleation / F-actin capping protein complex / negative regulation of filopodium assembly / regulation of cell projection assembly / actin cap / vesicle organization / postsynaptic actin cytoskeleton organization / vesicle transport along actin filament / regulation of actin filament polymerization / vesicle budding from membrane / positive regulation of chemotaxis / Clathrin-mediated endocytosis / cell junction assembly / COPI-independent Golgi-to-ER retrograde traffic / actin polymerization or depolymerization / barbed-end actin filament capping / protein-containing complex localization / dendritic spine morphogenesis / RHOF GTPase cycle / RHOD GTPase cycle / regulation of cell morphogenesis / regulation of lamellipodium assembly / Sensory processing of sound by inner hair cells of the cochlea / positive regulation of filopodium assembly / lamellipodium assembly / Neutrophil degranulation / regulation of postsynapse organization / cytoskeletal motor activator activity / cortical cytoskeleton / tropomyosin binding / mesenchyme migration / troponin I binding / myosin heavy chain binding / cell leading edge / filamentous actin / actin filament bundle / brush border / skeletal muscle thin filament assembly / striated muscle thin filament / actin filament bundle assembly / Advanced glycosylation endproduct receptor signaling / skeletal muscle myofibril / actin monomer binding / positive regulation of double-strand break repair via homologous recombination / cilium assembly / COPI-mediated anterograde transport / skeletal muscle fiber development / positive regulation of lamellipodium assembly / stress fiber / titin binding / cytoskeleton organization / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / cytoskeletal protein binding / MHC class II antigen presentation / actin filament polymerization / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / sarcomere / hippocampal mossy fiber to CA3 synapse / filopodium / cell projection / actin filament / response to bacterium / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / cell morphogenesis / Schaffer collateral - CA1 synapse / structural constituent of cytoskeleton / calcium-dependent protein binding / regulation of protein localization / actin filament binding / actin cytoskeleton / cell migration / lamellipodium / site of double-strand break / actin binding / Factors involved in megakaryocyte development and platelet production / cell cortex / cell body / actin cytoskeleton organization / cytoplasmic vesicle / protein-containing complex assembly / postsynapse / postsynaptic density / cytoskeleton / hydrolase activity / neuron projection / cadherin binding 類似検索 - 分子機能 Actin nucleation-promoting factor WAS, C-terminal / WASP family, EVH1 domain / Actin-related protein 2/3 complex subunit 5 / ARP2/3 complex 16 kDa subunit (p16-Arc) / Actin-related protein 2/3 complex subunit 2 / Actin-related protein 2/3 complex subunit 3 / Actin-related protein 2/3 complex subunit 4 / Actin-related protein 2/3 complex subunit 1 / Arp2/3 complex subunit 2/4 / Actin-related protein 2/3 complex subunit 5 superfamily ... Actin nucleation-promoting factor WAS, C-terminal / WASP family, EVH1 domain / Actin-related protein 2/3 complex subunit 5 / ARP2/3 complex 16 kDa subunit (p16-Arc) / Actin-related protein 2/3 complex subunit 2 / Actin-related protein 2/3 complex subunit 3 / Actin-related protein 2/3 complex subunit 4 / Actin-related protein 2/3 complex subunit 1 / Arp2/3 complex subunit 2/4 / Actin-related protein 2/3 complex subunit 5 superfamily / Actin-related protein 2/3 complex subunit 3 superfamily / Arp2/3 complex, 34 kD subunit p34-Arc / ARP2/3 complex ARPC3 (21 kDa) subunit / ARP2/3 complex 20 kDa subunit (ARPC4) / F-actin-capping protein subunit beta / F-actin capping protein, beta subunit, conserved site / F-actin-capping protein subunit beta, N-terminal domain / F-actin capping protein, beta subunit / F-actin capping protein beta subunit signature. / Wiskott Aldrich syndrome homology region 2 / F-actin capping protein, alpha subunit, conserved site / F-actin capping protein alpha subunit signature 1. / F-actin capping protein alpha subunit signature 2. / F-actin-capping protein subunit alpha / F-actin-capping protein subunit alpha/beta / F-actin-capping protein subunit alpha/beta, domain 2 / F-actin capping protein, alpha subunit, domain 1 / F-actin capping protein alpha subunit / WH2 motif / WH1/EVH1 domain / WH1 domain / WH1 domain profile. / WASP homology region 1 / WH2 domain / WH2 domain profile. / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / ATPase, nucleotide binding domain / PH-like domain superfamily / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily 類似検索 - ドメイン・相同性 Actin-related protein 2 / F-actin-capping protein subunit beta / F-actin-capping protein subunit alpha-1 / Actin-related protein 3 / Actin, alpha skeletal muscle / Actin-related protein 2/3 complex subunit 4 / Actin-related protein 2/3 complex subunit 1A / Actin-related protein 2/3 complex subunit 2 / Actin-related protein 2/3 complex subunit 5 / Actin-related protein 2/3 complex subunit 3 / Actin nucleation-promoting factor WASL 類似検索 - 構成要素生物種 Bos taurus (ウシ) / Oryctolagus cuniculus (ウサギ) / Homo sapiens (ヒト) / cattle (ウシ) / rabbit (ウサギ) / Mus musculus (ハツカネズミ)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.4 Å 詳細 データ登録者Rebowski G / van Eeuwen T / Boczkowska M / Dominguez R 資金援助 米国, 3件 詳細 詳細を隠すOrganization Grant number 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01-GM07391 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) T32-GM008275 米国 National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) F31-HL146077 米国
引用ジャーナル : To Be Published タイトル : Cryo-EM structure of an Arp2/3 complex mini-branch capped by capping protein (CapZ)著者 : Rebowski G / van Eeuwen T / Dominguez R / Boczkowska M 履歴 登録 2021年12月13日 - ヘッダ(付随情報) 公開 2023年6月14日 - マップ公開 2023年6月14日 - 更新 2023年8月2日 - 現状 2023年8月2日 処理サイト : RCSB / 状態 : 公開
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