7T1Z
Structure of the Fbw7-Skp1-MycNdegron complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-phase kinase-associated protein 1 | polymer | 149 | 16771.8 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 2 | B (B) | F-box/WD repeat-containing protein 7 | polymer | 457 | 51584.8 | 1 | UniProt (Q969H0) Pfam (PF00400) Pfam (PF12937) | Homo sapiens (human) | Archipelago homolog,hAgo,F-box and WD-40 domain-containing protein 7,F-box protein FBX30,SEL-10,hCdc4 |
| 3 | C (C) | Myc proto-oncogene N terminal degron | polymer | 20 | 2573.8 | 1 | UniProt (by SIFTS) (P01106) | Homo sapiens | |
| 4 | D, E, F, G, H (B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | I, J, K (A, B, C) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 2 - 163 (UniProt: P63208)
B: 263 - 707 (UniProt: Q969H0)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 84 | Pro 70 | linker |
| Gly 85 | Pro 71 | linker |
| Ser 86 | Pro 72 | linker |
| Gly 87 | Glu 73 | linker |
| Thr 88 | Asp 74 | linker |
| - | Arg 81 | deletion |
| - | Thr 82 | deletion |
| - | Asp 83 | deletion |
| - | Asp 84 | deletion |
| - | Ile 85 | deletion |
| - | Pro 86 | deletion |
| - | Val 87 | deletion |
| - | Trp 88 | deletion |
| Thr 160 | Cys 160 | conflict |
| Glu 163 | Lys 163 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| His 254 | - | expression tag |
| His 255 | - | expression tag |
| His 256 | - | expression tag |
| His 257 | - | expression tag |
| Gly 258 | - | expression tag |
| Gly 259 | - | expression tag |
| Ser 260 | - | expression tag |
| Gly 261 | - | expression tag |
| Met 262 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70930.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 480.3 | |
| All* | Total formula weight | 71410.7 |
