7T1Z

Structure of the Fbw7-Skp1-MycNdegron complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	S-phase kinase-associated protein 1	polymer	149	16771.8	1	UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB	Homo sapiens (human)	Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1
2	B	F-box/WD repeat-containing protein 7	polymer	457	51584.8	1	UniProt (Q969H0) Pfam (PF00400) Pfam (PF12937) In PDB	Homo sapiens (human)	Archipelago homolog,hAgo,F-box and WD-40 domain-containing protein 7,F-box protein FBX30,SEL-10,hCdc4
3	C	Myc proto-oncogene N terminal degron	polymer	20	2573.8	1	UniProt (by SIFTS) (P01106) In PDB	Homo sapiens
4	B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
5		water	water		18.0	99	Chemie (HOH)

Sequence modifications

A: 2 - 163 (UniProt: P63208)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 84	Pro 70	linker
Gly 85	Pro 71	linker
Ser 86	Pro 72	linker
Gly 87	Glu 73	linker
Thr 88	Asp 74	linker
-	Arg 81	deletion
-	Thr 82	deletion
-	Asp 83	deletion
-	Asp 84	deletion
-	Ile 85	deletion
-	Pro 86	deletion
-	Val 87	deletion
-	Trp 88	deletion
Thr 160	Cys 160	conflict
Glu 163	Lys 163	conflict

B: 263 - 707 (UniProt: Q969H0)

PDB	External Database	Details
Ser 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
His 256	-	expression tag
His 257	-	expression tag
Gly 258	-	expression tag
Gly 259	-	expression tag
Ser 260	-	expression tag
Gly 261	-	expression tag
Met 262	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	70930.3
Non-Polymers*	Number of molecules	5
	Total formula weight	480.3
All*	Total formula weight	71410.7

*Water molecules are not included.