7T1Z

Structure of the Fbw7-Skp1-MycNdegron complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IISGstDrTLKVWNA

Chain	Residue	Details
B	ILE434-ALA448
B	VAL474-ILE488
B	VAL554-VAL568
B	LEU594-ILE608
B	VAL637-LEU651

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by GSK3; alternate => ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:8386367, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	TPO58

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by DYRK2, GSK3 and CDK2 => ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20713526, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:8386367, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SEP62

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) threonine; alternate => ECO:0000269|PubMed:7642555

Chain	Residue	Details
C	TPO58

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS52

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