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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7T1Z

Structure of the Fbw7-Skp1-MycNdegron complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0006511biological_processubiquitin-dependent protein catabolic process
C0003700molecular_functionDNA-binding transcription factor activity
C0006355biological_processregulation of DNA-templated transcription
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IISGstDrTLKVWNA
ChainResidueDetails
BILE434-ALA448
BVAL474-ILE488
BVAL554-VAL568
BLEU594-ILE608
BVAL637-LEU651
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues46
DetailsDomain: {"description":"F-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00080","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues39
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues36
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues38
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues37
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by GSK3; alternate","evidences":[{"source":"PubMed","id":"15103331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17558397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30158517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8386367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"O-linked (GlcNAc) threonine; alternate","featureId":"CAR_000033","evidences":[{"source":"PubMed","id":"7642555","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-02-11

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