7T0S
Crystal structure of the BCL6 BTB domain in complex with OICR-11864
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Isoform 2 of B-cell lymphoma 6 protein | polymer | 127 | 14559.8 | 3 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | D, G, I (A, B, C) | 3-chloro-5-{1-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-hydroxybenzamide | non-polymer | 573.4 | 3 | Chemie (E2E) | |||
| 3 | E, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | J, K, L (A, B, C) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A, B, C: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 43679.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1939.8 | |
| All* | Total formula weight | 45619.3 |
