7SX7
Crystal structure of broadly neutralizing antibody N49P9.3-FR3-3 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | G, A | clade A/E 93TH057 HIV-1 gp120 core | polymer | 355 | 39356.6 | 2 | UniProt (A0A0M3KKW9) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
| 2 | H, B | N49P9.3-FR3-3 ANTIBODY FAB HEAVY CHAIN | polymer | 230 | 25050.2 | 2 | Homo (Human) | ||
| 3 | L, C | N49P9.3-FR3-3 ANTIBODY FAB LIGHT CHAIN | polymer | 203 | 21763.3 | 2 | Homo sapiens (Human) | ||
| 4 | A, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 23 | Chemie (NAG) | |||
| 5 | A, G | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 3 | Chemie (EPE) | |||
| 6 | water | water | 18.0 | 443 | Chemie (HOH) |
Sequence modifications
G, A: 44 - 492 (UniProt: A0A0M3KKW9)
| PDB | External Database | Details |
|---|---|---|
| Val 42 | - | expression tag |
| Pro 43 | - | expression tag |
| Ser 375 | His 242 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 172340.2 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 5802.7 | |
| All* | Total formula weight | 178142.9 |
