7SX4

Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium leak channel non-selective protein,Enhanced green fluorescent protein	polymer	2042	234128.8	1	UniProt (Q8IZF0) UniProt (A0A7G8ZY66) Pfam (PF00520)	Homo sapiens (human)	CanIon,Voltage gated channel-like protein 1
2	B (B)	Transmembrane protein FAM155A	polymer	483	54205.0	1	UniProt (B1AL88)	Homo sapiens (human)
3	C (C)	Calmodulin-1	polymer	149	16852.5	1	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (human)
4	D (D)	UNC79,Protein unc-79 homolog	polymer	2561	285174.9	1	UniProt (Q9P2D8) Pfam (PF14776)	Homo sapiens
5	E (E)	Protein unc-80 homolog	polymer	3283	366510.6	1	UniProt (Q8N2C7) Pfam (PF19424) Pfam (PF20262) Pfam (PF15778)	Homo sapiens (human)
6	F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	H (A)	(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE	non-polymer		720.0	1	Chemie (PEV)
8	I (A)	(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE	non-polymer		749.0	1	Chemie (PGV)
9	J, K, L (A)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	3	Chemie (Y01)

Sequence modifications

A: 1 - 1738 (UniProt: Q8IZF0)

PDB	External Database	Details
Gly 1739	-	linker
Gly 1740	-	linker
Ser 1741	-	linker
Leu 1742	-	linker
Val 1743	-	linker
Pro 1744	-	linker
Arg 1745	-	linker
Gly 1746	-	linker
Ser 1747	-	linker
Ser 1748	-	linker
Gly 1749	-	linker
Glu 1750	-	linker
Asn 1751	-	linker
Leu 1752	-	linker
Tyr 1753	-	linker
Phe 1754	-	linker
Gln 1755	-	linker
Gly 1756	-	linker
Ser 1757	-	linker
Ser 1758	-	linker
Gly 1759	-	linker

A: 1760 - 2000 (UniProt: A0A7G8ZY66)

PDB	External Database	Details
Lys 1966	Ala 207	conflict
Gly 2001	-	expression tag
Asp 2002	-	expression tag
Tyr 2003	-	expression tag
Lys 2004	-	expression tag
Asp 2005	-	expression tag
Asp 2006	-	expression tag
Asp 2007	-	expression tag
Asp 2008	-	expression tag
Lys 2009	-	expression tag
Gly 2010	-	expression tag
Ser 2011	-	expression tag
Gly 2012	-	expression tag
Ser 2013	-	expression tag
Ala 2014	-	expression tag
Trp 2015	-	expression tag
Ser 2016	-	expression tag
His 2017	-	expression tag
Pro 2018	-	expression tag
Gln 2019	-	expression tag
Phe 2020	-	expression tag
Glu 2021	-	expression tag
Lys 2022	-	expression tag
Gly 2023	-	expression tag
Gly 2024	-	expression tag
Gly 2025	-	expression tag
Ser 2026	-	expression tag
Gly 2027	-	expression tag
Gly 2028	-	expression tag
Gly 2029	-	expression tag
Ser 2030	-	expression tag
Gly 2031	-	expression tag
Gly 2032	-	expression tag
Ser 2033	-	expression tag
Ala 2034	-	expression tag
Trp 2035	-	expression tag
Ser 2036	-	expression tag
His 2037	-	expression tag
Pro 2038	-	expression tag
Gln 2039	-	expression tag
Phe 2040	-	expression tag
Glu 2041	-	expression tag
Lys 2042	-	expression tag

B: 1 - 458 (UniProt: B1AL88)

PDB	External Database	Details
Gly 459	-	expression tag
Gly 460	-	expression tag
Ser 461	-	expression tag
Gly 462	-	expression tag
Gly 463	-	expression tag
Ser 464	-	expression tag
Asp 465	-	expression tag
Tyr 466	-	expression tag
Lys 467	-	expression tag
Asp 468	-	expression tag
Asp 469	-	expression tag
Asp 470	-	expression tag
Asp 471	-	expression tag
Lys 472	-	expression tag
Gly 473	-	expression tag
Asn 474	-	expression tag
Ser 475	-	expression tag
Asp 476	-	expression tag
Tyr 477	-	expression tag
Lys 478	-	expression tag
Asp 479	-	expression tag
Asp 480	-	expression tag
Asp 481	-	expression tag
Asp 482	-	expression tag
Lys 483	-	expression tag

D: 38 - 165 (PDB: 7SX4)
D: 174 - 2635 (UniProt: Q9P2D8)

PDB	External Database	Details
Gly 2636	-	expression tag
Gly 2637	-	expression tag
Ser 2638	-	expression tag
Gly 2639	-	expression tag
Gly 2640	-	expression tag
Ser 2641	-	expression tag
Asp 2642	-	expression tag
Tyr 2643	-	expression tag
Lys 2644	-	expression tag
Asp 2645	-	expression tag
Asp 2646	-	expression tag
Asp 2647	-	expression tag
Asp 2648	-	expression tag
Lys 2649	-	expression tag
Gly 2650	-	expression tag
Asn 2651	-	expression tag
Ser 2652	-	expression tag
Asp 2653	-	expression tag
Tyr 2654	-	expression tag
Lys 2655	-	expression tag
Asp 2656	-	expression tag
Asp 2657	-	expression tag
Asp 2658	-	expression tag
Asp 2659	-	expression tag
Lys 2660	-	expression tag

E: 1 - 3258 (UniProt: Q8N2C7)

PDB	External Database	Details
Gly 3259	-	expression tag
Gly 3260	-	expression tag
Ser 3261	-	expression tag
Gly 3262	-	expression tag
Gly 3263	-	expression tag
Ser 3264	-	expression tag
Asp 3265	-	expression tag
Tyr 3266	-	expression tag
Lys 3267	-	expression tag
Asp 3268	-	expression tag
Asp 3269	-	expression tag
Asp 3270	-	expression tag
Asp 3271	-	expression tag
Lys 3272	-	expression tag
Gly 3273	-	expression tag
Asn 3274	-	expression tag
Ser 3275	-	expression tag
Asp 3276	-	expression tag
Tyr 3277	-	expression tag
Lys 3278	-	expression tag
Asp 3279	-	expression tag
Asp 3280	-	expression tag
Asp 3281	-	expression tag
Asp 3282	-	expression tag
Lys 3283	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	956871.9
Non-Polymers*	Number of molecules	7
	Total formula weight	3371.6
All*	Total formula weight	960243.5

*Water molecules are not included.