7SX4
Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| A | 0022840 | molecular_function | leak channel activity |
| A | 0032224 | biological_process | positive regulation of synaptic transmission, cholinergic |
| A | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060075 | biological_process | regulation of resting membrane potential |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015275 | molecular_function | stretch-activated, monoatomic cation-selective, calcium channel activity |
| B | 0098703 | biological_process | calcium ion import across plasma membrane |
| C | 0000086 | biological_process | G2/M transition of mitotic cell cycle |
| C | 0000922 | cellular_component | spindle pole |
| C | 0002027 | biological_process | regulation of heart rate |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005513 | biological_process | detection of calcium ion |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005813 | cellular_component | centrosome |
| C | 0005819 | cellular_component | spindle |
| C | 0005829 | cellular_component | cytosol |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005876 | cellular_component | spindle microtubule |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0008076 | cellular_component | voltage-gated potassium channel complex |
| C | 0010800 | biological_process | positive regulation of peptidyl-threonine phosphorylation |
| C | 0010801 | biological_process | negative regulation of peptidyl-threonine phosphorylation |
| C | 0010856 | molecular_function | adenylate cyclase activator activity |
| C | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| C | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| C | 0016020 | cellular_component | membrane |
| C | 0016240 | biological_process | autophagosome membrane docking |
| C | 0019855 | molecular_function | calcium channel inhibitor activity |
| C | 0019901 | molecular_function | protein kinase binding |
| C | 0021762 | biological_process | substantia nigra development |
| C | 0030017 | cellular_component | sarcomere |
| C | 0031432 | molecular_function | titin binding |
| C | 0031514 | cellular_component | motile cilium |
| C | 0031954 | biological_process | positive regulation of protein autophosphorylation |
| C | 0031982 | cellular_component | vesicle |
| C | 0032465 | biological_process | regulation of cytokinesis |
| C | 0032516 | biological_process | positive regulation of phosphoprotein phosphatase activity |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0034704 | cellular_component | calcium channel complex |
| C | 0035307 | biological_process | positive regulation of protein dephosphorylation |
| C | 0035458 | biological_process | cellular response to interferon-beta |
| C | 0043209 | cellular_component | myelin sheath |
| C | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| C | 0044325 | molecular_function | transmembrane transporter binding |
| C | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048306 | molecular_function | calcium-dependent protein binding |
| C | 0050848 | biological_process | regulation of calcium-mediated signaling |
| C | 0051343 | biological_process | positive regulation of cyclic-nucleotide phosphodiesterase activity |
| C | 0051592 | biological_process | response to calcium ion |
| C | 0055117 | biological_process | regulation of cardiac muscle contraction |
| C | 0060314 | biological_process | regulation of ryanodine-sensitive calcium-release channel activity |
| C | 0060315 | biological_process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| C | 0060316 | biological_process | positive regulation of ryanodine-sensitive calcium-release channel activity |
| C | 0071346 | biological_process | cellular response to type II interferon |
| C | 0071902 | biological_process | positive regulation of protein serine/threonine kinase activity |
| C | 0072542 | molecular_function | protein phosphatase activator activity |
| C | 0097225 | cellular_component | sperm midpiece |
| C | 0098901 | biological_process | regulation of cardiac muscle cell action potential |
| C | 0140056 | biological_process | organelle localization by membrane tethering |
| C | 1901842 | biological_process | negative regulation of high voltage-gated calcium channel activity |
| C | 1901844 | biological_process | regulation of cell communication by electrical coupling involved in cardiac conduction |
| C | 1902494 | cellular_component | catalytic complex |
| C | 1905913 | biological_process | negative regulation of calcium ion export across plasma membrane |
| C | 1990456 | biological_process | mitochondrion-endoplasmic reticulum membrane tethering |
| D | 0005886 | cellular_component | plasma membrane |
| E | 0005261 | molecular_function | monoatomic cation channel activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0030424 | cellular_component | axon |
| E | 0034703 | cellular_component | cation channel complex |
| E | 0055080 | biological_process | monoatomic cation homeostasis |
| E | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| C | ASP21-LEU33 | |
| C | ASP57-PHE69 | |
| C | ASP94-LEU106 | |
| C | ASP130-PHE142 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| E | PRO2268-ASN2288 | |
| C | GLU68 | |
| A | ILE1261-SER1271 | |
| A | VAL1319-SER1331 | |
| A | GLU1448-ILE1738 | |
| E | ILE2398-LEU2418 | |
| E | GLY2785-PHE2805 | |
| E | LEU2831-LEU2851 | |
| C | GLU32 | |
| C | ASP57 | |
| C | ASP59 | |
| C | ASN61 | |
| C | THR63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BLN6 |
| Chain | Residue | Details |
| E | SER257 | |
| C | GLU141 | |
| E | SER525 | |
| E | SER3042 | |
| C | TYR100 | |
| C | GLU105 | |
| C | ASP130 | |
| C | ASP132 | |
| C | ASP134 | |
| C | GLN136 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| C | ALA2 | |
| A | PRO973-SER980 | |
| A | ALA1040-ALA1104 | |
| A | ILE1125-GLY1129 | |
| A | SER1228-PRO1236 | |
| A | LEU1294-ASN1296 | |
| A | GLY1358-ALA1378 | |
| A | MET1399-TYR1420 | |
| A | ALA130-SER137 | |
| A | PHE200-SER269 | |
| A | ILE290-PRO294 | |
| A | ASN404-ASP416 | |
| A | LEU469-SER472 | |
| A | VAL531-ALA543 | |
| A | LEU564-HIS569 | |
| A | SER907-ALA915 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS22 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29 |
| Chain | Residue | Details |
| C | THR45 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER82 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS95 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | TYR100 | |
| A | PHE544-THR563 | |
| A | MET1105-ILE1124 | |
| A | ILE1379-CYS1398 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER102 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | THR111 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| C | LYS116 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | TYR139 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157 |
| Chain | Residue | Details |
| C | LYS22 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLY503-PHE530 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | MET570-LEU599 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | TYR887-GLU906 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO916-ALA939 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ALA948-MET972 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLY981-MET1003 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLU1016-PHE1039 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO1130-PHE1159 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PHE1211-LEU1227 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | VAL1237-ILE1260 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ARG1272-ALA1293 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ALA1297-HIS1318 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | MET1332-PHE1357 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ALA1421-VAL1447 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33203861, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| A | ASN210 | |
| A | ASN216 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32698188, ECO:0000269|PubMed:33203861, ECO:0007744|PDB:6XIW, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| A | ASN1064 |
