7SU0
Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C, D | Cytotoxic T-lymphocyte protein 4 | polymer | 125 | 13555.4 | 2 | UniProt (P16410) Pfam (PF07686) In PDB | Homo sapiens (Human) | Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4 |
2 | H, I | Fab heavy chain | polymer | 229 | 24749.7 | 2 | Homo sapiens (Human) | ||
3 | L, M | Fab light chain | polymer | 215 | 23527.0 | 2 | Homo sapiens (Human) | ||
4 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
5 | I | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
6 | M | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
7 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 118 (UniProt: P16410)
PDB | External Database | Details |
---|---|---|
Gly 119 | - | expression tag |
His 120 | - | expression tag |
His 121 | - | expression tag |
His 122 | - | expression tag |
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 123664.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 958.8 | |
All* | Total formula weight | 124623.1 |