7SSE
Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DDB1- and CUL4-associated factor 1 | polymer | 315 | 35592.9 | 2 | UniProt (Q9Y4B6) | Homo sapiens (human) | HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein |
| 2 | C (A) | N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine | non-polymer | 357.4 | 1 | Chemie (B1I) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A, B: 1077 - 1390 (UniProt: Q9Y4B6)
| PDB | External Database | Details |
|---|---|---|
| Gly 1076 | - | expression tag |
| Ala 1077 | Phe 1077 | engineered mutation |
| Ala 1079 | Arg 1079 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71185.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 357.4 | |
| All* | Total formula weight | 71543.3 |
