7SR6
Human Endogenous Retrovirus (HERV-K) reverse transcriptase ternary complex with dsDNA template Primer and dNTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E, F (A, B, F, G) | Polymerase | polymer | 618 | 70136.9 | 4 | UniProt (V9H0F6) Pfam (PF00078) Pfam (PF06817) Pfam (PF00075) UniProt (by SIFTS) (Q9UQG0) | Homo sapiens (human) | |
| 2 | C, G (D, H) | DNA (5'-D(P*GP*GP*GP*AP*CP*CP*TP*GP*AP*AP*AP*GP*CP*GP*AP*AP*AP*GP*GP*GP*AP*AP*A)-3') | polymer | 24 | 7510.9 | 2 | Homo sapiens | ||
| 3 | D, H (E, I) | DNA (5'-D(P*TP*TP*TP*CP*CP*CP*TP*TP*TP*CP*GP*CP*TP*TP*TP*CP*AP*GP*GP*T)-3') | polymer | 21 | 6362.1 | 2 | Homo sapiens | ||
| 4 | I, LA, NA, SB, T (A, D, F, G) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 5 | J (A) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DCP) | |||
| 6 | AA, BA, BB, CA, CB... (B, F, G, A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 34 | Chemie (DIO) | |||
| 7 | AB, GA, OB, P, RA... (F, B, G, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 8 | GB, HA, HB, IA, JA... (F, B, D, A, G) | POTASSIUM ION | non-polymer | 39.1 | 11 | Chemie (K) | |||
| 9 | JB, Y (G, B) | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | non-polymer | 266.3 | 2 | Chemie (PG6) | |||
| 10 | QA (F) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) | |||
| 11 | FB, PB (F, G) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 12 | TB, UB, VB, WB, XB... (A, B, D, E, F...) | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A, B, F, G: 1 - 596 (UniProt: V9H0F6)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| Ala -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Tyr -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Ile -10 | - | expression tag |
| Pro -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 308293.7 | |
| Non-Polymers* | Number of molecules | 63 |
| Total formula weight | 5534.5 | |
| All* | Total formula weight | 313828.3 |
