7SN8

Cryo-EM structure of Drosophila Integrator cleavage module (IntS4-IntS9-IntS11) in complex with IP6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D	Integrator complex subunit 4	polymer	1032	114728.9	1	UniProt (Q9W3E1) In PDB	Drosophila melanogaster (fruit fly)
2	K	Integrator complex subunit 11	polymer	597	67683.9	1	UniProt (Q9VAH9) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF21386) In PDB	Drosophila melanogaster (fruit fly)
3	I	Integrator complex subunit 9	polymer	654	73351.5	1	UniProt (Q95TS5) Pfam (PF16661) Pfam (PF10996) Pfam (PF21382) In PDB	Drosophila melanogaster (fruit fly)
4	K	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	I	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)

Sequence modifications

D: 1 - 1022 (UniProt: Q9W3E1)

PDB	External Database	Details
Met -9	-	initiating methionine
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	255764.3
Non-Polymers*	Number of molecules	3
	Total formula weight	790.9
All*	Total formula weight	256555.2

*Water molecules are not included.