7SN8
Cryo-EM structure of Drosophila Integrator cleavage module (IntS4-IntS9-IntS11) in complex with IP6
Functional Information from GO Data
Chain | GOid | namespace | contents |
D | 0000822 | molecular_function | inositol hexakisphosphate binding |
D | 0005634 | cellular_component | nucleus |
D | 0016180 | biological_process | snRNA processing |
D | 0032039 | cellular_component | integrator complex |
D | 0034472 | biological_process | snRNA 3'-end processing |
D | 0160232 | cellular_component | INTAC complex |
D | 0160240 | biological_process | RNA polymerase II transcription initiation surveillance |
I | 0000822 | molecular_function | inositol hexakisphosphate binding |
I | 0005515 | molecular_function | protein binding |
I | 0005634 | cellular_component | nucleus |
I | 0005829 | cellular_component | cytosol |
I | 0016180 | biological_process | snRNA processing |
I | 0030514 | biological_process | negative regulation of BMP signaling pathway |
I | 0032039 | cellular_component | integrator complex |
I | 0034472 | biological_process | snRNA 3'-end processing |
I | 0090101 | biological_process | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
I | 0090287 | biological_process | regulation of cellular response to growth factor stimulus |
I | 0160232 | cellular_component | INTAC complex |
I | 0160240 | biological_process | RNA polymerase II transcription initiation surveillance |
K | 0000822 | molecular_function | inositol hexakisphosphate binding |
K | 0004521 | molecular_function | RNA endonuclease activity |
K | 0005515 | molecular_function | protein binding |
K | 0005634 | cellular_component | nucleus |
K | 0005737 | cellular_component | cytoplasm |
K | 0005829 | cellular_component | cytosol |
K | 0016180 | biological_process | snRNA processing |
K | 0016787 | molecular_function | hydrolase activity |
K | 0031123 | biological_process | RNA 3'-end processing |
K | 0032039 | cellular_component | integrator complex |
K | 0034472 | biological_process | snRNA 3'-end processing |
K | 0046872 | molecular_function | metal ion binding |
K | 0160232 | cellular_component | INTAC complex |
K | 0160240 | biological_process | RNA polymerase II transcription initiation surveillance |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 9 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"36180473","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SN8","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"36180473","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | Motif: {"description":"HXHXDH motif"} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | Active site: {"evidences":[{"source":"PubMed","id":"31530651","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31809743","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 7 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"36180473","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39032490","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SN8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UIC","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |