7SN8

Cryo-EM structure of Drosophila Integrator cleavage module (IntS4-IntS9-IntS11) in complex with IP6

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000822	molecular_function	inositol hexakisphosphate binding
D	0005634	cellular_component	nucleus
D	0016180	biological_process	snRNA processing
D	0032039	cellular_component	integrator complex
D	0034472	biological_process	snRNA 3'-end processing
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
I	0000822	molecular_function	inositol hexakisphosphate binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0016180	biological_process	snRNA processing
I	0030514	biological_process	negative regulation of BMP signaling pathway
I	0031123	biological_process	RNA 3'-end processing
I	0032039	cellular_component	integrator complex
I	0034472	biological_process	snRNA 3'-end processing
I	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
I	0090287	biological_process	regulation of cellular response to growth factor stimulus
I	0160232	cellular_component	INTAC complex
I	0160240	biological_process	RNA polymerase II transcription initiation surveillance
K	0000822	molecular_function	inositol hexakisphosphate binding
K	0004521	molecular_function	RNA endonuclease activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0016180	biological_process	snRNA processing
K	0016787	molecular_function	hydrolase activity
K	0031123	biological_process	RNA 3'-end processing
K	0032039	cellular_component	integrator complex
K	0034472	biological_process	snRNA 3'-end processing
K	0046872	molecular_function	metal ion binding
K	0160232	cellular_component	INTAC complex
K	0160240	biological_process	RNA polymerase II transcription initiation surveillance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:36180473, ECO:0007744|PDB:7SN8

Chain	Residue	Details
I	MET1
I	ARG2
I	THR18
I	PHE19
I	ARG504
I	LYS508
I	ARG509

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:36180473, ECO:0000269|PubMed:39032490, ECO:0007744|PDB:7SN8, ECO:0007744|PDB:8UIC

Chain	Residue	Details
K	HIS68
K	HIS70
K	ASP72
K	HIS73
K	HIS157
K	ASP178
K	HIS414

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:36180473, ECO:0007744|PDB:7SN8

Chain	Residue	Details
K	LYS462

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