7SLP

Cryo-EM structure of 7SK core RNP with linear RNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	7SK snRNA methylphosphate capping enzyme	polymer	309	35122.8	1	UniProt (Q7L2J0) Pfam (PF06859)	Homo sapiens (human)	MePCE,Bicoid-interacting protein 3 homolog,Bin3 homolog
2	B (B)	La-related protein 7	polymer	480	55109.1	1	UniProt (Q4G0J3) Pfam (PF05383) Pfam (PF00076) Pfam (PF08777)	Homo sapiens (human)	La ribonucleoprotein domain family member 7,hLARP7,P-TEFb-interaction protein for 7SK stability,PIP7S
3	C (R)	Linear 7SK RNA	polymer	81	26096.2	1		Homo sapiens
4	D (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)

Sequence modifications

A: 400 - 689 (UniProt: Q7L2J0)

PDB	External Database	Details
Met 381	-	expression tag
Gly 382	-	expression tag
Ser 383	-	expression tag
Ser 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
Ser 391	-	expression tag
Ser 392	-	expression tag
Gly 393	-	expression tag
Leu 394	-	expression tag
Val 395	-	expression tag
Pro 396	-	expression tag
Arg 397	-	expression tag
Gly 398	-	expression tag
Ser 399	-	expression tag

B: 1 - 369 (UniProt: Q4G0J3)

PDB	External Database	Details
Gly 0	-	expression tag

B: 370 - 582 (UniProt: Q4G0J3)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	116328.2
Non-Polymers*	Number of molecules	1
	Total formula weight	384.4
All*	Total formula weight	116712.6

*Water molecules are not included.