7SJ3
Structure of CDK4-Cyclin D3 bound to abemaciclib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 4 | polymer | 311 | 34762.7 | 1 | UniProt (P11802) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 4,PSK-J3 |
| 2 | B (B) | G1/S-specific cyclin-D3 | polymer | 259 | 29294.3 | 1 | UniProt (P30281) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | |
| 3 | C (A) | N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | non-polymer | 506.6 | 1 | Chemie (6ZV) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 2 - 303 (UniProt: P11802)
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| Glu 304 | - | expression tag |
| Gly 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
| His 308 | - | expression tag |
| His 309 | - | expression tag |
| His 310 | - | expression tag |
| His 311 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64056.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 506.6 | |
| All* | Total formula weight | 64563.5 |
