7SJ3

Structure of CDK4-Cyclin D3 bound to abemaciclib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000166	molecular_function	nucleotide binding
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000785	cellular_component	chromatin
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005923	cellular_component	bicellular tight junction
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009410	biological_process	response to xenobiotic stimulus
A	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
A	0010468	biological_process	regulation of gene expression
A	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
A	0016740	molecular_function	transferase activity
A	0030332	molecular_function	cyclin binding
A	0031965	cellular_component	nuclear membrane
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0060260	biological_process	regulation of transcription initiation by RNA polymerase II
A	0061469	biological_process	regulation of type B pancreatic cell proliferation
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071353	biological_process	cellular response to interleukin-4
A	0097128	cellular_component	cyclin D1-CDK4 complex
A	0097129	cellular_component	cyclin D2-CDK4 complex
A	0097130	cellular_component	cyclin D3-CDK4 complex
A	0106310	molecular_function	protein serine kinase activity
A	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
A	1904637	biological_process	cellular response to ionomycin

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK

Chain	Residue	Details
A	ILE12-LYS35

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV

Chain	Residue	Details
A	ILE136-VAL148

---

site_id	PS00292
Number of Residues	32
Details	CYCLINS Cyclins signature. RkmLayWMlevceeqrCeeevFplAMnYLDRY

Chain	Residue	Details
B	ARG57-TYR88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"Required for binding D-type cyclins"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16782892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19237555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19237565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19487459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	125
Details	Domain: {"description":"Cyclin N-terminal"}

Chain

Residue

Details

---