7SHZ
IgE-Fc in complex with HAE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H, I, J (B, A, H, G) | IgE Fc | polymer | 247 | 27550.9 | 4 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | Immunoglobulin heavy constant epsilon, Ig epsilon chain C region,Ig epsilon chain C region ND |
| 2 | B, C, D, K (K, C, I, E) | HAE Variable fragment Heavy chain | polymer | 123 | 13477.0 | 4 | Homo sapiens | ||
| 3 | E, F, G, L (L, D, J, F) | HAE Variable fragment Light chain | polymer | 135 | 14623.8 | 4 | Homo sapiens | ||
| 4 | M (M) | alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G97616MU) | |||
| 5 | N (N) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 6 | O (O) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 7 | P, X, Y (B, H, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 8 | Q, R (C) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 9 | S (C) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 10 | T, Z (D, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 11 | U, V (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (MAN) | |||
| 12 | W (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 13 | AA, BA, CA, DA, EA... (B, K, C, I, L...) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
B, A, H, G: 328 - 545 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Ala 299 | - | expression tag |
| Pro 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ala 302 | - | expression tag |
| Glu 303 | - | expression tag |
| Gly 304 | - | expression tag |
| Gly 305 | - | expression tag |
| Gly 306 | - | expression tag |
| Gln 307 | - | expression tag |
| Asn 308 | - | expression tag |
| His 309 | - | expression tag |
| His 310 | - | expression tag |
| His 311 | - | expression tag |
| His 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| Gly 317 | - | expression tag |
| Gly 318 | - | expression tag |
| Glu 319 | - | expression tag |
| Asn 320 | - | expression tag |
| Leu 321 | - | expression tag |
| Tyr 322 | - | expression tag |
| Phe 323 | - | expression tag |
| Gln 324 | - | expression tag |
| Gly 325 | - | expression tag |
| Gly 326 | - | expression tag |
| Ser 327 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 222606.8 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 3056.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1489.2 | |
| All* | Total formula weight | 227152.7 |
