7SHF
Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | C | Isoform 2 of Regulator of G-protein signaling 7 | polymer | 469 | 54761.9 | 1 | UniProt (P49802) Pfam (PF00610) Pfam (PF18148) Pfam (PF00631) Pfam (PF00615) In PDB | Homo sapiens (human) | RGS7 |
| 2 | D | Guanine nucleotide-binding protein subunit beta-5 | polymer | 353 | 38778.6 | 1 | UniProt (P62881) Pfam (PF00400) In PDB | Mus musculus (house mouse) | Gbeta5,Transducin beta chain 5 |
| 3 | B, A | G-protein coupled receptor 158 | polymer | 781 | 88251.6 | 2 | UniProt (Q5T848) Pfam (PF22572) Pfam (PF00003) In PDB | Homo sapiens (human) | GPR |
| 4 | B, A | CHOLESTEROL | non-polymer | 386.7 | 22 | Chemie (CLR) | |||
| 5 | A | (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate | non-polymer | 887.1 | 1 | Chemie (EIJ) | |||
| 6 | A | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 1 | Chemie (PEE) |
Sequence modifications
B, A: 1 - 775 (UniProt: Q5T848)
| PDB | External Database | Details |
|---|---|---|
| Leu 776 | - | expression tag |
| Glu 777 | - | expression tag |
| Val 778 | - | expression tag |
| Leu 779 | - | expression tag |
| Phe 780 | - | expression tag |
| Gln 781 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 270043.7 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 10137.5 | |
| All* | Total formula weight | 280181.3 |
