7SGZ
Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Checkpoint protein RAD24 | polymer | 659 | 75823.5 | 1 | UniProt (P32641) Pfam (PF03215) | Saccharomyces cerevisiae (Baker's yeast) | |
| 2 | B (B) | Replication factor C subunit 4 | polymer | 323 | 36201.0 | 1 | UniProt (P40339) Pfam (PF00004) Pfam (PF08542) | Saccharomyces cerevisiae (Baker's yeast) | Replication factor C4,Activator 1 37 kDa subunit |
| 3 | C (C) | Replication factor C subunit 3 | polymer | 340 | 38254.5 | 1 | UniProt (P38629) Pfam (PF00004) Pfam (PF08542) | Saccharomyces cerevisiae (Baker's yeast) | Replication factor C3,Activator 1 40 kDa subunit |
| 4 | D (D) | Replication factor C subunit 2 | polymer | 353 | 39794.5 | 1 | UniProt (P40348) Pfam (PF00004) Pfam (PF21960) Pfam (PF08542) | Saccharomyces cerevisiae (Baker's yeast) | Replication factor C2,Activator 1 41 kDa subunit |
| 5 | E (E) | Replication factor C subunit 5 | polymer | 354 | 39993.6 | 1 | UniProt (P38251) Pfam (PF21960) Pfam (PF22534) Pfam (PF13177) | Saccharomyces cerevisiae (Baker's yeast) | Replication factor C5,Activator 1 40 kDa subunit |
| 6 | F (F) | Mitosis Entry Checkpoint protein MEC3 | polymer | 460 | 51606.1 | 1 | UniProt (A0A6A5PTK1) Pfam (PF04005) UniProt (by SIFTS) (Q02574) | Saccharomyces cerevisiae (Baker's yeast) | DNA damage checkpoint control protein MEC3,Y55_G0029450.mRNA.1.CDS.1 |
| 7 | G (G) | DNA damage checkpoint control protein RAD17 | polymer | 401 | 45637.5 | 1 | UniProt (P48581) Pfam (PF02144) | Saccharomyces cerevisiae (Baker's yeast) | DNA repair exonuclease RAD17 |
| 8 | H (H) | DNA Damage Checkpoint protein DDC1 | polymer | 593 | 67386.8 | 1 | UniProt (A0A7I9C529) UniProt (by SIFTS) (Q08949) | Saccharomyces cerevisiae (Baker's yeast) | |
| 9 | I (P) | Watson strand | polymer | 20 | 6136.0 | 1 | synthetic construct | ||
| 10 | J (T) | Crick strand | polymer | 40 | 12214.8 | 1 | synthetic construct | ||
| 11 | K, M, O, Q (A, B, C, D) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 4 | Chemie (AGS) | |||
| 12 | L, N, P, R (A, B, C, E) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 13 | S (E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 14 | T (E) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) |
Sequence modifications
F: 1 - 474 (UniProt: A0A6A5PTK1)
H: 1 - 612 (UniProt: A0A7I9C529)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 446 | deletion |
| - | Gly 447 | deletion |
| - | Ser 448 | deletion |
| - | Leu 449 | deletion |
| - | Glu 450 | deletion |
| - | Asp 451 | deletion |
| - | Ser 452 | deletion |
| - | Glu 453 | deletion |
| - | Asp 454 | deletion |
| - | Val 455 | deletion |
| - | Glu 456 | deletion |
| - | Lys 457 | deletion |
| - | Pro 458 | deletion |
| - | Arg 459 | deletion |
| PDB | External Database | Details |
|---|---|---|
| - | Thr 301 | deletion |
| - | Ile 302 | deletion |
| - | Glu 303 | deletion |
| - | Asp 304 | deletion |
| - | Glu 305 | deletion |
| - | Lys 306 | deletion |
| - | Gln 307 | deletion |
| - | Asp 308 | deletion |
| - | Lys 309 | deletion |
| - | Arg 310 | deletion |
| - | Ser 311 | deletion |
| - | His 312 | deletion |
| - | Ser 313 | deletion |
| - | Lys 314 | deletion |
| - | Arg 315 | deletion |
| - | Arg 316 | deletion |
| - | Glu 317 | deletion |
| - | His 318 | deletion |
| - | Met 319 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 413048.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2712.4 | |
| All* | Total formula weight | 415760.8 |
