7SEM
Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | MPE8 Fab heavy chain | polymer | 228 | 23985.8 | 1 | Homo sapiens | ||
2 | F | Fusion glycoprotein F0 | polymer | 551 | 60357.6 | 1 | UniProt (H6X1Z0) Pfam (PF00523) In PDB | Human metapneumovirus | Fusion glycoprotein F1,Fusion glycoprotein F2 |
3 | C | MPE8 Fab light chain | polymer | 216 | 22772.1 | 1 | Homo sapiens | ||
4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
5 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
F: 1 - 490 (UniProt: H6X1Z0)
PDB | External Database | Details |
---|---|---|
Arg 100 | Gln 100 | conflict |
Arg 101 | Ser 101 | conflict |
Cys 127 | Thr 127 | conflict |
Cys 153 | Asn 153 | conflict |
Pro 185 | Ala 185 | conflict |
Cys 365 | Thr 365 | conflict |
Asn 368 | His 368 | conflict |
Cys 463 | Val 463 | conflict |
Gly 491 | - | expression tag |
Gly 492 | - | expression tag |
Gly 493 | - | expression tag |
Ser 494 | - | expression tag |
Gly 495 | - | expression tag |
Tyr 496 | - | expression tag |
Ile 497 | - | expression tag |
Pro 498 | - | expression tag |
Glu 499 | - | expression tag |
Ala 500 | - | expression tag |
Pro 501 | - | expression tag |
Arg 502 | - | expression tag |
Asp 503 | - | expression tag |
Gly 504 | - | expression tag |
Gln 505 | - | expression tag |
Ala 506 | - | expression tag |
Tyr 507 | - | expression tag |
Val 508 | - | expression tag |
Arg 509 | - | expression tag |
Lys 510 | - | expression tag |
Asp 511 | - | expression tag |
Gly 512 | - | expression tag |
Glu 513 | - | expression tag |
Trp 514 | - | expression tag |
Val 515 | - | expression tag |
Leu 516 | - | expression tag |
Leu 517 | - | expression tag |
Ser 518 | - | expression tag |
Thr 519 | - | expression tag |
Phe 520 | - | expression tag |
Leu 521 | - | expression tag |
Gly 522 | - | expression tag |
Arg 523 | - | expression tag |
Ser 524 | - | expression tag |
Leu 525 | - | expression tag |
Glu 526 | - | expression tag |
Val 527 | - | expression tag |
Leu 528 | - | expression tag |
Phe 529 | - | expression tag |
Gln 530 | - | expression tag |
Gly 531 | - | expression tag |
Pro 532 | - | expression tag |
Gly 533 | - | expression tag |
His 534 | - | expression tag |
His 535 | - | expression tag |
His 536 | - | expression tag |
His 537 | - | expression tag |
His 538 | - | expression tag |
His 539 | - | expression tag |
His 540 | - | expression tag |
His 541 | - | expression tag |
Ser 542 | - | expression tag |
Ala 543 | - | expression tag |
Trp 544 | - | expression tag |
Ser 545 | - | expression tag |
His 546 | - | expression tag |
Pro 547 | - | expression tag |
Gln 548 | - | expression tag |
Phe 549 | - | expression tag |
Glu 550 | - | expression tag |
Lys 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 107115.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 107779.1 |