7SD3
Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, N, M | 4E10 Fab light chain | polymer | 214 | 23292.7 | 3 | Homo sapiens | ||
2 | G, K, I | 4E10 Fab heavy chain | polymer | 230 | 24180.3 | 3 | Homo sapiens | ||
3 | A, C, E | Envelope glycoprotein gp120 | polymer | 481 | 54064.3 | 3 | UniProt (A0A6H1VID3) Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6) In PDB | HIV whole-genome vector AA1305#18 | Envelope glycoprotein gp160,Glycoprotein 120,Surface protein gp120,Transmembrane protein gp41 |
4 | B, D, F | Transmembrane protein gp41 | polymer | 173 | 19800.6 | 3 | UniProt (A0A173DX29) Pfam (PF00517) UniProt (by SIFTS) (Q2N0S6) In PDB | HIV whole-genome vector AA1305#18 | Env polyprotein |
5 | J, O, P, R, S... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
6 | L, Q, T | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
7 | A, E, F, B, C... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 36 | Chemie (NAG) |
Sequence modifications
A, C, E: 31 - 506 (UniProt: A0A6H1VID3)
B, D, F: 512 - 684 (UniProt: A0A173DX29)
PDB | External Database | Details |
---|---|---|
Ser 374 | Tyr 373 | conflict |
Cys 499 | Ala 498 | conflict |
Arg 507 | - | expression tag |
Arg 508 | - | expression tag |
Arg 509 | - | expression tag |
Arg 510 | - | expression tag |
Arg 511 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | conflict |
Cys 605 | Thr 602 | conflict |
Leu 684 | Ile 681 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 364013.4 | |
Branched | Number of molecules | 9 |
Total formula weight | 4792.5 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 7963.5 | |
All* | Total formula weight | 376769.3 |