7SCX
KRAS full-length G12V in complex with RGL1 Ras association domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 188 | 21485.6 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (B) | Ral guanine nucleotide dissociation stimulator-like 1 | polymer | 93 | 10695.0 | 1 | UniProt (Q9NZL6) Pfam (PF00788) | Homo sapiens (Human) | RalGDS-like 1 |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 5 | E (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A: 1 - 188 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Val 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32180.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 658.5 | |
| All* | Total formula weight | 32839.2 |
