7S8H
Structure of Lassa virus glycoprotein bound to Fab 18.5C and Fab 36.1F
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycoprotein G1 | polymer | 201 | 22928.0 | 1 | UniProt (P08669) Pfam (PF00798) | Lassa virus | GP1 |
| 2 | B (H) | 18.5C Fab Heavy Chain | polymer | 228 | 24309.4 | 1 | Homo sapiens | ||
| 3 | C (L) | 18.5C Fab Light Chain | polymer | 217 | 23654.2 | 1 | Homo sapiens | ||
| 4 | D (B) | 36.1F Fab Heavy Chain | polymer | 229 | 24174.2 | 1 | Homo sapiens | ||
| 5 | E (C) | 36.1F Fab Light Chain | polymer | 216 | 23671.3 | 1 | Homo sapiens | ||
| 6 | F (a) | Glycoprotein G2 | polymer | 165 | 19117.7 | 1 | UniProt (P08669) Pfam (PF00798) | Lassa virus | GP2 |
| 7 | G (D) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 8 | H, J, L, M, N (E, G, J, K, M) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 9 | I (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 10 | K, O (I, N) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 2 | In PDB GlyTouCan (G82348BZ) | |||
| 11 | P (a) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 12 | Q, R, S, T, U... (A, H, L, B, C...) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 59 - 259 (UniProt: P08669)
a: 260 - 424 (UniProt: P08669)
| PDB | External Database | Details |
|---|---|---|
| Cys 243 | Gly 243 | engineered mutation |
| Arg 258 | Leu 258 | engineered mutation |
| Arg 259 | Leu 259 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 329 | Glu 329 | engineered mutation |
| Thr 332 | Met 332 | engineered mutation |
| Cys 350 | Ile 350 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 137854.8 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5555.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 143631.1 |
