7S46

PAK4cat (D440N/S474E) in complex with Integrin beta5 760-770 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isoform 2 of Serine/threonine-protein kinase PAK 4	polymer	346	39084.2	1	UniProt (O96013) Pfam (PF00069) In PDB	Homo sapiens (Human)	p21-activated kinase 4,PAK-4
2	B	Integrin beta-5	polymer	11	1358.5	1	UniProt (P18084) In PDB	Homo sapiens
3	A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
4		water	water		18.0	67	Chemie (HOH)

Sequence modifications

A: 274 - 591 (UniProt: O96013)

PDB	External Database	Details
Met 246	-	initiating methionine
Gly 247	-	expression tag
Ser 248	-	expression tag
Ser 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
Ser 256	-	expression tag
Ser 257	-	expression tag
Gly 258	-	expression tag
Leu 259	-	expression tag
Val 260	-	expression tag
Pro 261	-	expression tag
Arg 262	-	expression tag
Gly 263	-	expression tag
Ser 264	-	expression tag
His 265	-	expression tag
Met 266	-	expression tag
Glu 267	-	expression tag
Asn 268	-	expression tag
Leu 269	-	expression tag
Tyr 270	-	expression tag
Phe 271	-	expression tag
Gln 272	-	expression tag
Gly 273	-	expression tag
Asn 440	Asp 275	engineered mutation
Glu 474	Ser 309	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40442.7
Non-Polymers*	Number of molecules	1
	Total formula weight	506.2
All*	Total formula weight	40948.9

*Water molecules are not included.