7S3V
Structure of HsKYNase_66, an evolved variant of human kynureninase with greatly increased activity towards kynurenine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Kynureninase | polymer | 465 | 53009.8 | 2 | UniProt (Q16719) Pfam (PF22580) In PDB | Homo sapiens (Human) | L-kynurenine hydrolase |
Sequence modifications
A, B: 1 - 465 (UniProt: Q16719)
PDB | External Database | Details |
---|---|---|
Asp 67 | Asn 67 | engineered mutation |
Asn 72 | Leu 72 | engineered mutation |
Ile 99 | Ala 99 | engineered mutation |
Trp 102 | His 102 | engineered mutation |
Phe 103 | Glu 103 | engineered mutation |
Glu 104 | Val 104 | engineered mutation |
Asp 106 | Lys 106 | engineered mutation |
Ser 107 | Arg 107 | engineered mutation |
His 111 | Thr 111 | engineered mutation |
Tyr 112 | Gly 112 | engineered mutation |
Val 132 | Ala 132 | engineered mutation |
Thr 136 | Ala 136 | engineered mutation |
Ile 189 | Met 189 | engineered mutation |
Ile 223 | Val 223 | engineered mutation |
Tyr 225 | Phe 225 | engineered mutation |
Gly 274 | Ser 274 | engineered mutation |
Ser 280 | Ala 280 | engineered mutation |
Ser 281 | Gly 281 | engineered mutation |
Pro 282 | Ala 282 | engineered mutation |
Cys 331 | Ile 331 | engineered mutation |
Thr 333 | Asn 333 | engineered mutation |
Ile 341 | Ser 341 | engineered mutation |
Leu 405 | Ile 405 | engineered mutation |
Asn 408 | Ser 408 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 106019.7 | |
All* | Total formula weight | 106019.7 |