7S3V

Structure of HsKYNase_66, an evolved variant of human kynureninase with greatly increased activity towards kynurenine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006569	biological_process	L-tryptophan catabolic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0019805	biological_process	quinolinate biosynthetic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0030429	molecular_function	kynureninase activity
A	0034341	biological_process	response to type II interferon
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0034516	biological_process	response to vitamin B6
A	0042803	molecular_function	protein homodimerization activity
A	0097053	biological_process	obsolete L-kynurenine catabolic process
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006569	biological_process	L-tryptophan catabolic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0019805	biological_process	quinolinate biosynthetic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0030429	molecular_function	kynureninase activity
B	0034341	biological_process	response to type II interferon
B	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
B	0034516	biological_process	response to vitamin B6
B	0042803	molecular_function	protein homodimerization activity
B	0097053	biological_process	obsolete L-kynurenine catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03017","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03017","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17300176","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details