7RX7
Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | N6-adenosine-methyltransferase 70 kDa subunit | polymer | 225 | 25732.5 | 1 | UniProt (Q86U44) Pfam (PF05063) In PDB | Homo sapiens (Human) | MT-A70,Methyltransferase-like protein 3 |
| 2 | B | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 349 | 39513.6 | 1 | UniProt (Q9HCE5) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | water | water | 18.0 | 464 | Chemie (HOH) |
Sequence modifications
A: 357 - 580 (UniProt: Q86U44)
B: 111 - 456 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gly 110 | - | expression tag |
| Pro 298 | Arg 298 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65246.1 | |
| All* | Total formula weight | 65246.1 |
