7RQU
Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, B, D) | Transient receptor potential cation channel subfamily V member 1 | polymer | 868 | 98719.8 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | DA, E, MA, P (B, A, D, C) | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) | |||
| 3 | EA, F, KA, L, NA... (B, A, D, C) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 8 | Chemie (LBN) | |||
| 4 | BA, CA, FA, G, GA... (B, A, D, C) | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 20 | Chemie (6OU) | |||
| 5 | AA, LA, M, V (B, D, A, C) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol | non-polymer | 749.0 | 4 | Chemie (YFP) | |||
| 6 | N, O (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) |
Sequence modifications
A, C, B, D: 1 - 838 (UniProt: O35433)
| PDB | External Database | Details |
|---|---|---|
| Glu 839 | - | expression tag |
| Asn 840 | - | expression tag |
| Ser 841 | - | expression tag |
| Leu 842 | - | expression tag |
| Glu 843 | - | expression tag |
| Val 844 | - | expression tag |
| Leu 845 | - | expression tag |
| Phe 846 | - | expression tag |
| Gln 847 | - | expression tag |
| Gly 848 | - | expression tag |
| Pro 849 | - | expression tag |
| Asp 850 | - | expression tag |
| Tyr 851 | - | expression tag |
| Lys 852 | - | expression tag |
| Asp 853 | - | expression tag |
| Asp 854 | - | expression tag |
| Asp 855 | - | expression tag |
| Asp 856 | - | expression tag |
| Lys 857 | - | expression tag |
| Ala 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
| His 862 | - | expression tag |
| His 863 | - | expression tag |
| His 864 | - | expression tag |
| His 865 | - | expression tag |
| His 866 | - | expression tag |
| His 867 | - | expression tag |
| His 868 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 394879.0 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 25997.4 | |
| All* | Total formula weight | 420876.4 |
