7RLE
Crystal structure of PPAR gamma in complex with CREB-binding protein and agonist GW1929
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Peroxisome proliferator-activated receptor gamma | polymer | 276 | 31506.6 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | B, D (B, D) | CREB-binding protein | polymer | 24 | 2425.7 | 2 | UniProt (Q92793) | Homo sapiens | Histone lysine acetyltransferase CREBBP,Protein-lysine acetyltransferase CREBBP |
| 3 | E, F (A, C) | (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid | non-polymer | 495.6 | 2 | Chemie (EDK) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, C: 203 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 202 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67864.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 991.1 | |
| All* | Total formula weight | 68855.7 |
