7RK7

The complex between TIL 1383i TCR and human Class I MHC HLA-A2 with the bound Tyrosinase(369-377)(N371D) nonameric peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, A alpha chain	polymer	275	31854.2	1	UniProt (P04439) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (Human)	Human leukocyte antigen A,HLA-A
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	Tyrosinase peptide	polymer	9	1031.2	1	UniProt (P14679)	Homo sapiens	LB24-AB,Monophenol monooxygenase,SK29-AB,Tumor rejection antigen AB
4	D (D)	TIL1383i (h3T) T cell receptor alpha chain	polymer	214	23655.3	1		Homo sapiens (Human)
5	E (E)	TIL1383i (h3T) T cell receptor beta chain	polymer	253	28619.7	1		Homo sapiens (Human)
6	F, G, H, I, J (A, B, C, D, E)	water	water		18.0	82	Chemie (HOH)

Sequence modifications

A: 1 - 275 (UniProt: P04439)

PDB	External Database	Details
Gly 62	Gln 86	conflict
Lys 66	Asn 90	conflict
His 70	Gln 94	conflict
His 74	Asp 98	conflict
Val 95	Ile 119	conflict
Arg 97	Ile 121	conflict
Trp 107	Gly 131	conflict
His 114	Arg 138	conflict
Tyr 116	Asp 140	conflict
Lys 127	Asn 151	conflict
Thr 142	Ile 166	conflict
His 145	Arg 169	conflict
Val 152	Glu 176	conflict
Glu 161	Asp 185	conflict
Ala 184	Pro 208	conflict
Ala 193	Pro 217	conflict
Val 194	Ile 218	conflict
Ser 207	Gly 231	conflict
Gln 253	Glu 277	conflict

B: 2 - 100 (UniProt: P61769)

PDB	External Database	Details
Met 1	-	initiating methionine

C: 1 - 9 (UniProt: P14679)

PDB	External Database	Details
Asp 3	Asn 371	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	97039.8
All*	Total formula weight	97039.8

*Water molecules are not included.