7RJP
Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with SHMT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B | Serine hydroxymethyltransferase, cytosolic | polymer | 6 | 758.9 | 1 | UniProt (P34896) In PDB | Homo sapiens | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | A | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
| 5 | A, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 15858.3 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 479.9 | |
| All* | Total formula weight | 16338.2 |
