7RJ4
Co-crystal structure of lenacapavir bound to N74D mutant of disulfide stabilized HIV-1 CA hexamer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | CAPSID PROTEIN P24 | polymer | 231 | 25462.3 | 3 | UniProt (B6DRA0) Pfam (PF00607) Pfam (PF19317) UniProt (by SIFTS) (P12493) | Human immunodeficiency virus 1 | |
| 2 | D, L, T (A, B, C) | Lenacapavir | non-polymer | 968.3 | 3 | Chemie (QNG) | |||
| 3 | E, F, G, H, I... (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 18 | Chemie (CL) | |||
| 4 | AA, K, S (C, A, B) | IODIDE ION | non-polymer | 126.9 | 3 | Chemie (IOD) | |||
| 5 | BA, CA, DA (A, B, C) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 231 (UniProt: B6DRA0)
| PDB | External Database | Details |
|---|---|---|
| Cys 14 | Ala 146 | engineered mutation |
| Cys 45 | Glu 177 | engineered mutation |
| Asp 74 | Asn 206 | engineered mutation |
| Ala 184 | Trp 316 | engineered mutation |
| Ala 185 | Met 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 76386.8 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3923.7 | |
| All* | Total formula weight | 80310.5 |
